Overview
Cordycepin, also known as 3'-deoxyadenosine, is a nucleoside analog derived from Cordyceps militaris and other Cordyceps fungi. It is a naturally occurring compound with significant biological activity, extensively researched for its pharmacological potential. Cordycepin is structurally similar to adenosine but lacks a hydroxyl group at the 3' position of its ribose moiety, which contributes to its unique properties. First isolated in the 1950s, cordycepin has since been studied for its diverse effects, including immune modulation, anti-inflammatory, and antitumor activities. It is commonly extracted from cultured Cordyceps or synthesized chemically for use in pharmaceuticals and health supplements.
Physical and Chemical Properties
Cordycepin is a white to off-white crystalline powder with a molecular weight of 251.24 g/mol. It is soluble in water and polar organic solvents like DMSO but has limited solubility in non-polar solvents. The compound decomposes at temperatures above 225°C, making it sensitive to high heat. Its chemical structure, C10H13N5O3, includes a modified ribose sugar, which prevents normal RNA chain elongation, giving it potential antiviral and anticancer properties. Analytical methods like HPLC and NMR are used to confirm its purity and identity in commercial and research settings.
Main Applications
Cordycepin is primarily used in the pharmaceutical and nutraceutical industries. It is investigated for its role in inhibiting tumor growth, reducing inflammation, and enhancing immune function. In traditional medicine, Cordyceps extracts containing cordycepin are used to combat fatigue and improve respiratory health. In research, cordycepin serves as a tool to study RNA synthesis inhibition and cellular processes. It is also incorporated into dietary supplements marketed for energy enhancement and immune support, often in combination with other bioactive compounds.
Safety and Storage
Cordycepin should be handled with standard laboratory precautions, including gloves and eye protection, to avoid irritation. It is stable under recommended storage conditions (2-8°C, protected from light and moisture) but may degrade if exposed to heat or prolonged humidity. While generally considered safe at low doses in supplements, high concentrations may have cytotoxic effects. Regulatory guidelines vary by region, so manufacturers must ensure compliance with local safety standards. Bulk storage requires airtight containers with desiccants to maintain stability.
B2B Procurement Guide
When procuring cordycepin, prioritize suppliers with verified certifications (e.g., ISO, GMP) and transparent testing protocols. Key specifications include purity (≥98% by HPLC), absence of heavy metals, and microbial limits. Request certificates of analysis (CoA) for each batch. Pricing varies based on quantity and purity, with bulk purchases (kilograms) often discounted. Lead times depend on sourcing—synthetic cordycepin may be more readily available than naturally extracted variants. Consider partnering with suppliers specializing in bioactive compounds for consistent quality.
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