Overview
Clebopride is a synthetic compound that acts as a dopamine D2 receptor antagonist. It is primarily used in the pharmaceutical industry for its antiemetic and gastroprokinetic properties. The compound is known for its effectiveness in enhancing gastrointestinal motility and alleviating symptoms of nausea and vomiting. Clebopride is commonly utilized in clinical settings to treat conditions such as gastroparesis and functional dyspepsia. As a pharmaceutical active ingredient, Clebopride is subject to stringent regulatory standards to ensure its safety and efficacy. It is typically formulated into tablets or injectable solutions for medical use. The compound's mechanism of action involves blocking dopamine receptors in the chemoreceptor trigger zone, which helps reduce nausea and vomiting.
Physical and Chemical Properties
Clebopride appears as a white to off-white crystalline powder with a molecular weight of 311.81 g/mol. It has a melting point of approximately 150-152°C, indicating its stability under normal storage conditions. The compound is soluble in both water and organic solvents, which facilitates its formulation into various pharmaceutical dosage forms. The molecular formula of Clebopride is C15H22ClN3O2, and it is classified as a benzamide derivative. Its solubility profile makes it suitable for oral and parenteral administration. The compound's stability is maintained when stored in a cool, dry environment, away from direct light and moisture, which could degrade its potency over time.
Main Applications
Clebopride is primarily used in the treatment of gastrointestinal motility disorders such as gastroparesis and functional dyspepsia. Its gastroprokinetic effects help stimulate gastric emptying and improve digestive function. Additionally, its antiemetic properties make it effective in managing nausea and vomiting associated with chemotherapy, postoperative recovery, and other medical conditions. The compound is also investigated for potential applications in other areas of medicine, including psychiatric disorders, due to its dopamine receptor antagonism. However, its primary use remains within gastroenterology, where it is valued for its ability to enhance motility and reduce symptoms of gastrointestinal distress.
Safety and Storage
Clebopride should be handled with care to avoid inhalation or direct skin contact, as it may cause irritation. Proper personal protective equipment, such as gloves and masks, should be used when handling the compound in its pure form. Storage conditions should adhere to pharmaceutical standards, keeping the substance in a cool, dry place away from light and moisture to maintain its stability. In clinical use, Clebopride is generally well-tolerated, but side effects such as drowsiness, dizziness, and extrapyramidal symptoms may occur. Patients with a history of hypersensitivity to benzamide derivatives should avoid using this medication. Always consult a healthcare professional before administration.
B2B Procurement Guide
When procuring Clebopride, it is essential to verify the supplier's compliance with Good Manufacturing Practices (GMP) and other regulatory standards. Pharmaceutical-grade Clebopride must meet stringent purity and quality criteria to ensure its safety and efficacy in medical applications. Buyers should request certificates of analysis (CoA) and other relevant documentation to confirm the product's specifications. Price ranges for Clebopride can vary significantly depending on the supplier, quantity, and purity level. Bulk purchases may offer cost advantages, but it is crucial to balance cost with quality. Establish long-term relationships with reputable suppliers to ensure consistent quality and reliable delivery schedules.
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