Overview
Chrysin is a bioactive flavonoid classified as a flavone, first isolated from the blue passionflower (Passiflora caerulea). As a 源叶标准品 (reference standard), it serves as a critical benchmark in quality control for herbal extracts and synthetic derivatives. Its natural sources include honey, propolis, and Oroxylum indicum bark. Industrially, it is synthesized via the Allan-Robinson reaction or extracted from plant matrices. The compound gained attention for its potential health benefits, though clinical evidence remains limited. In B2B contexts, chrysin is typically supplied as a high-purity analytical standard (e.g., ≥98% by HPLC) for research and manufacturing. Major producers include pharmaceutical chemical suppliers and specialized botanical extract companies.
Physical and Chemical Properties
Chrysin crystallizes as pale yellow needles with a characteristic flavonoid structure featuring hydroxyl groups at positions 5 and 7. Its UV-Vis spectrum shows maxima at 268 nm and 310 nm, useful for analytical identification. The compound exhibits moderate thermal stability but degrades under prolonged UV exposure. Chemically, chrysin acts as a chelating agent for metal ions like Fe²⁺, contributing to its antioxidant effects. Its low water solubility limits bioavailability, prompting derivatization (e.g., chrysin-7-O-beta-D-glucuronide) for drug delivery systems. The flavone core is resistant to acidic hydrolysis but undergoes methylation or glycosylation in metabolic processes.
Main Applications
In pharmaceuticals, chrysin is studied for its anti-inflammatory effects via NF-κB pathway inhibition and potential in metabolic syndrome management. It serves as a lead compound for developing novel anxiolytics due to GABA_A receptor modulation. The nutraceutical industry incorporates chrysin in testosterone-boosting supplements, though efficacy is debated. Cosmetic formulations leverage its antioxidant properties to counteract UV-induced skin aging. As a reference standard, it is essential for quantifying flavonoid content in propolis extracts, herbal medicines, and functional foods under ISO and pharmacopoeia methods.
Safety and Storage
Chrysin has an LD50 >2,000 mg/kg (oral, rats), indicating low acute toxicity. However, prolonged high doses may affect hormone levels. Occupational handling requires nitrile gloves and dust masks to prevent inhalation of fine particles. For storage, amber glass vials with PTFE-lined caps are recommended to minimize oxidation. Bulk quantities should be kept under nitrogen atmosphere. Stability testing indicates ≤2% degradation over 24 months when stored at 4°C with desiccant. Shipping typically follows ambient temperature regulations for non-hazardous solids.
B2B Procurement Guide
When sourcing chrysin standard品, prioritize suppliers with ISO 17025 accreditation for reference materials. Key due diligence includes: 1. Batch-specific COA with HPLC chromatograms (USP <621> compliance) 2. Residual solvent analysis (e.g., DMSO <500 ppm) 3. Microbial limits testing for cosmetic/pharma applications For bulk orders (>1 kg), negotiate tiered pricing and request pre-shipment samples. EU/US buyers should confirm REACH/TSCA registration status. Spot prices fluctuate with bee propolis harvest yields, so consider forward contracts during off-seasons.
Related Manufacturers
- 主营：单磷酸、白果酸、银杏酸、白杨素、澳洲茄胺、红四氮唑、白当归脑、曲氟胸苷、安石榴苷、二磷酸葡、白术内酯、四氮唑蓝、澳洲茄碱、巴卡亭iii、白藜芦醇、脱氧尿苷、澳洲茄边、白当归素、脱氧腺苷、腺苷一水合、二磷酸钠盐、白花前胡丙、羟甲香豆素、尿苷三磷酸、菝葜皂苷元、磷酸二钠盐
- 主营：白杨素、白蜡树素、百两金素、半齿泽兰素
- 主营：夹竹桃、异奥卡、香附酮、标准品、儿茶素、白鲜碱、管花苷、紫檀芪、木栓醇、豆甾醇、植酸锌、苏木素、泽泻醇、龙血素、黄柏酮、蚱蜢酮、防己碱、葫芦素、乌甲素、印楝素、厚朴酚、皂苷元、双黄酮、樱桃苷、芝麻素
- 主营：白杨素、桉脂素、化学试剂、β-香树脂酮
- 主营：苦参碱母液、黑米花青素、白芍提取物芍药苷、白杨素99、苦参提取物、枸杞提取物、侧柏叶提取物
- 主营：阻燃剂、拉那白、牛儿酮、白杨素、海藻糖、热敏蓝、萘磺酸、氯菊酯、硫酸锌、催化剂、杨梅酯、檀香醚、聚醚胺、吸收剂、脂檀油、苍术素、羟钴胺、转移剂、溶剂绿、麝香酮、王浆酸、芬多精、纤维素、新戊酯、王冠醚、遮甜粉
- 主营：标准品、对照品
- 主营：叔碳酸、十八醛、溶菌酶、白杨素、海藻糖、癸二醇、氨基丙基、氢路噻嗪、邻苯二甲、乙基碳二、羟基癸酸、正十七烷、谷胱甘肽、烷二甲醇、松果体素、vc磷酸酯镁、2-甲基丁醛、朱栾倍半萜、丁烷四乙酸、表面活性剂、癸烷撑二醇、缩水甘油邻、10-羟基羊蜡酸、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：有机原料、中间体、香精香料、白杨素、催化剂、有机硅、表面活性剂
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、白杨素、10-羟基癸酸、苯乙烯磷酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、乙烯基磷酸二乙酯、磷酸锰铁锂、β-磷酸三钙、十一烯酸、钨酸铝、1-乙炔基环已醇、间二异丙苯、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：甘氨酸、水苏糖、阻燃剂、白杨素、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、1680-21-3、牛磺酸、褪黑素、磷酸铁、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、磷酸铝、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉、乙氧基
- 主营：白杨素、硅油树脂、中间体、香精香料
- 主营：精萃宝对照品、一叶萩碱、三叶豆紫檀苷、标准品、羟基红花黄色素A、苍术素、苍术酮、盐酸血根碱、盐酸白屈菜红碱、药根碱、藁本内酯、欧当归内酯A、高丽槐素、松果菊苷、马钱苷、莫诺苷
- 主营：天然化合物、分析试剂、细胞实验、中药标准品、标准品对照品、标准品、动物实验、中药提取物、单体化合物、科研实验用
- 主营：桤木酮、bakuchiol、秦皮素、白杨素、阿魏酸、黄连碱、试剂盒、14475-63-9、氢鄂贝定、湖贝甲素、高三尖杉、白蜡树苷、胰蛋白酶、贝母素甲、贝母素乙、西贝母碱、裕贝甲素、金丝桃素、白蜡树素、萃淋树脂、苍术内酯i、土贝母苷丙、补骨脂甲素、氢浙贝母碱、氨基异丁酸、葡萄糖二酸
- 主营：果蔬粉、金银花绿原酸、平卧菊三七黄酮、白杨素、大豆苷元、水杨甙、肽粉、山楂黄酮、姜黄素、PQQ