Chromane-4-one
Overview
Chromane-4-one, also known as 4-chromanone, is an organic compound with the molecular formula C9H8O2. It is a derivative of chromane and serves as a versatile intermediate in chemical synthesis. The compound is widely used in pharmaceutical and fragrance industries due to its structural properties. Chromane-4-one is synthesized through various chemical routes, including oxidation and cyclization reactions. Its stable aromatic structure makes it valuable for further functionalization in drug development and specialty chemicals.
Physical and Chemical Properties
Chromane-4-one appears as a white to pale yellow crystalline powder with a characteristic aromatic odor. It has a melting point of approximately 60-65°C and is soluble in common organic solvents such as ethanol and acetone, though it has limited solubility in water. The compound's key chemical properties include its reactivity as a ketone, which allows it to participate in condensation and reduction reactions. These properties make it a useful building block in synthetic organic chemistry, particularly for creating heterocyclic compounds.
Main Applications
Chromane-4-one is primarily used as an intermediate in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). Its structure is a core component in the development of drugs targeting cardiovascular and neurological conditions. Additionally, the compound finds applications in the fragrance industry, where it contributes to the synthesis of aromatic compounds. Its use in organic synthesis extends to agrochemicals and specialty chemicals, highlighting its versatility.
Safety and Storage
Chromane-4-one should be handled with care to avoid skin and eye contact, as it may cause irritation. Proper personal protective equipment (PPE), including gloves and goggles, is recommended during handling. Storage conditions include keeping the compound in a cool, dry place away from direct sunlight and moisture. Containers should be tightly sealed to prevent contamination and degradation. In case of spillage, absorb with inert material and dispose of according to local regulations.
B2B Procurement Guide
When procuring Chromane-4-one, buyers should verify the CAS number (491-37-2) and purity specifications to ensure product quality. Reputable suppliers often provide certificates of analysis (CoA) for batch verification. Bulk pricing varies depending on quantity and supplier. It is advisable to request samples and compare lead times before placing large orders. Additionally, inquire about packaging options and compliance with international shipping regulations for seamless logistics.
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