Overview
Alpha-Chlorohydrin (α-Chlorohydrin) is an organochlorine compound derived from glycerol. It is widely used in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. Due to its reactive nature, it serves as a versatile intermediate in organic synthesis. The compound is produced by the chlorination of glycerol, resulting in a mixture of mono- and dichlorohydrins. Its unique chemical properties make it valuable in various industrial applications, though it requires careful handling due to its toxicity.
Physical and Chemical Properties
Alpha-Chlorohydrin is a colorless to pale yellow viscous liquid with a density of 1.32 g/cm³. It has a melting point of -40 °C and a boiling point of 213 °C. The compound is hygroscopic and miscible with water, alcohol, and ether. Its chemical reactivity stems from the presence of both hydroxyl and chlorine functional groups, which allow it to participate in nucleophilic substitution and esterification reactions. These properties make it a useful building block in synthetic chemistry.
Main Applications
In the pharmaceutical industry, Alpha-Chlorohydrin is used as an intermediate in the synthesis of drugs, including beta-blockers and antifungals. It also plays a role in the production of agrochemicals, such as herbicides and insecticides. Industrially, it serves as a solvent and a precursor for epoxy resins and plasticizers. Its ability to modify polymers and act as a cross-linking agent makes it valuable in material science.
Safety and Storage
Alpha-Chlorohydrin is moderately toxic and can cause skin, eye, and respiratory irritation. Proper personal protective equipment (PPE), including gloves and goggles, should be worn when handling this chemical. Storage should be in a cool, dry, well-ventilated area, away from heat sources and open flames. Containers must be tightly sealed to prevent moisture absorption and degradation.
B2B Procurement Guide
When procuring Alpha-Chlorohydrin, buyers should prioritize suppliers with certifications such as ISO 9001. Requesting a safety data sheet (SDS) is essential to ensure compliance with regulatory standards. Bulk purchases may offer cost advantages, but buyers should verify the compound's purity and shelf life. Transport and storage conditions should align with safety guidelines to prevent hazards.
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