Overview
Chelidonine is a naturally occurring benzylisoquinoline alkaloid primarily extracted from the greater celandine plant (Chelidonium majus). It has been used in traditional medicine for centuries, particularly in European folk remedies. In modern times, chelidonine has gained attention in pharmaceutical research due to its potential biological activities, including antispasmodic, anti-inflammatory, and anticancer properties. The compound is typically isolated through solvent extraction and chromatographic purification processes. High-purity chelidonine (≥98%) is commonly required for research purposes, particularly in pharmacological studies investigating its mechanisms of action and potential therapeutic applications.
Physical and Chemical Properties
Chelidonine appears as a white to pale yellow crystalline powder with a melting point between 135-137°C. Its molecular structure contains a benzylisoquinoline backbone, which contributes to its biological activity. The compound is relatively stable under normal conditions but should be protected from prolonged exposure to light and moisture to prevent degradation. In terms of solubility, chelidonine demonstrates good solubility in organic solvents such as ethanol, methanol, and chloroform, but has limited solubility in water. This property influences its extraction methods and formulation approaches for potential pharmaceutical applications. The compound's UV absorption characteristics make it suitable for analytical detection using HPLC with UV detection.
Main Applications
The primary application of chelidonine is in pharmaceutical research, where it serves as a lead compound for drug development. Studies have investigated its potential as an anticancer agent, with particular interest in its ability to induce apoptosis in certain cancer cell lines. Traditional medicine systems have used chelidonine-containing preparations for various ailments, though modern clinical applications require further validation. In the nutraceutical industry, standardized extracts containing chelidonine are sometimes incorporated into supplements, though regulatory status varies by region. Research continues to explore its potential applications in pain management, digestive disorders, and as an antimicrobial agent. The compound's mechanism of action appears to involve interactions with multiple cellular targets, including microtubules and various enzymes.
Safety and Storage
Chelidonine requires careful handling due to its potential toxicity at higher concentrations. Appropriate personal protective equipment (PPE), including gloves and eye protection, should be used when working with the pure compound. The material safety data sheet (MSDS) should be consulted before handling. For storage, chelidonine should be kept in tightly sealed containers in a cool, dry environment, preferably at temperatures between 2-8°C for long-term preservation. Protection from light is recommended to maintain stability. Under proper storage conditions, high-purity chelidonine can typically maintain its quality for several years. Stability testing should be conducted for critical applications.
B2B Procurement Guide
When sourcing high-purity chelidonine, buyers should prioritize suppliers who can provide comprehensive analytical documentation, including certificates of analysis (COA) with HPLC purity data (preferably ≥98%). Reputable suppliers should demonstrate good manufacturing practices (GMP) compliance for pharmaceutical-grade material. Key procurement considerations include batch-to-batch consistency, residual solvent levels (if applicable), and microbiological quality. For research applications, small-scale samples should be evaluated before committing to larger purchases. Buyers should verify supplier credentials and consider audit reports if available. Pricing varies significantly based on quantity, purity, and supplier reputation, with bulk purchases typically offering better value.
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