Overview
Chelerythrine is a benzophenanthridine alkaloid primarily extracted from plants such as Chelidonium majus (greater celandine). It is known for its bright yellow-orange color and significant biological activity. The compound has been extensively studied for its pharmacological properties, including its role as a protein kinase C inhibitor. Chelerythrine's unique structure allows it to interact with various biological targets, making it valuable in medical and biochemical research. Its natural origin and potent effects have spurred interest in its potential therapeutic applications, particularly in treating cancer and inflammatory conditions.
Physical and Chemical Properties
Chelerythrine appears as a yellow to orange crystalline powder with a melting point around 200-202°C. It is soluble in organic solvents like ethanol, methanol, and DMSO but has limited solubility in water. The compound's stability is influenced by light and moisture, requiring proper storage conditions to maintain its integrity. Its molecular formula is C21H18NO4+, with a molecular weight of 348.37 g/mol. Chelerythrine's cationic nature contributes to its ability to interact with cellular membranes and proteins, which is central to its biological activity. These properties make it a versatile tool in laboratory and clinical settings.
Main Applications
Chelerythrine is widely used in pharmaceutical research due to its antimicrobial, anti-inflammatory, and anticancer properties. It has shown promise in inhibiting the growth of cancer cells and reducing inflammation in preclinical studies. Additionally, its role as a protein kinase C inhibitor makes it valuable in studying signal transduction pathways. The compound is also explored for its potential in treating cardiovascular diseases and microbial infections. Its broad-spectrum activity and natural origin enhance its appeal for developing new therapeutic agents. Researchers continue to investigate its mechanisms and applications in various medical fields.
Safety and Storage
Chelerythrine should be handled with care, as it may cause skin and eye irritation. Proper personal protective equipment, including gloves and goggles, is recommended when working with this compound. It should be stored in a cool, dry place, protected from light and moisture to prevent degradation. Long-term storage may require inert atmospheres or desiccants to maintain stability. Disposal should comply with local regulations for chemical waste. Safety data sheets (SDS) provided by suppliers offer detailed guidelines for handling and emergency measures.
B2B Procurement Guide
When procuring chelerythrine, buyers should prioritize suppliers who provide detailed documentation, including Certificates of Analysis (CoA) and purity reports. The reference price ranges from approximately $50 to $200 per gram, depending on purity and supplier reliability. Bulk purchases may offer cost savings, but it's essential to verify storage and handling requirements to ensure product quality. Reputable suppliers often provide technical support and customized packaging options. Buyers should also consider logistics, such as shipping conditions and lead times, to align with project timelines.
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