Overview
Cefcapene is a third-generation cephalosporin antibiotic derived from 7-aminocephalosporanic acid. It is classified as a beta-lactam antibiotic and is structurally similar to other cephalosporins, with enhanced stability against beta-lactamases. The drug is commonly administered orally in the form of cefcapene pivoxil, a prodrug that improves absorption. Developed in the late 20th century, cefcapene is widely used in Japan and other Asian countries for treating bacterial infections. Its broad-spectrum activity makes it effective against pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
Physical and Chemical Properties
Cefcapene appears as a white to pale yellow crystalline powder with a molecular weight of 519.57 g/mol. It is slightly soluble in water but dissolves well in methanol and other organic solvents. The compound decomposes at temperatures around 160-165°C, making it unsuitable for high-temperature processing. Its molecular formula, C20H25N5O7S2, includes a beta-lactam ring, which is critical for its antibacterial activity. The presence of a pivoxil ester in its prodrug form enhances oral bioavailability by facilitating absorption in the gastrointestinal tract.
Main Applications
Cefcapene is primarily used to treat bacterial infections, including respiratory tract infections (e.g., bronchitis, pneumonia), urinary tract infections, and skin infections. Its broad-spectrum activity covers both gram-positive and gram-negative bacteria, making it a versatile therapeutic option. In clinical settings, cefcapene pivoxil is often prescribed for pediatric and adult patients due to its favorable pharmacokinetics and safety profile. It is particularly effective against beta-lactamase-producing strains, which are resistant to many other antibiotics.
Safety and Storage
Cefcapene should be stored in a cool, dry place below 25°C, protected from light and moisture to prevent degradation. Improper storage can lead to reduced potency and efficacy. The compound is generally safe but may cause allergic reactions in individuals sensitive to beta-lactam antibiotics. Healthcare providers should monitor patients for adverse effects such as gastrointestinal disturbances, skin rashes, and, in rare cases, anaphylaxis. It is contraindicated in patients with a history of severe penicillin or cephalosporin allergies.
B2B Procurement Guide
When procuring cefcapene for pharmaceutical use, buyers should prioritize suppliers with certified Good Manufacturing Practice (GMP) compliance. Verify the CAS number (105889-45-0) and request certificates of analysis to ensure purity and quality. The reference price range is approximately $200-$500 per kg, but prices may vary based on quantity, supplier, and regional regulations. Bulk purchases often qualify for discounts. Ensure proper documentation for import/export compliance, especially for controlled substances.
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