Overview
CD5 antibody is a biological reagent designed to bind specifically to the CD5 protein, a surface marker predominantly found on T cells and a subset of B cells. It is widely used in immunology research, diagnostics, and therapeutic development. The antibody is available in various forms, including monoclonal and polyclonal variants, each suited for different applications such as flow cytometry, immunohistochemistry (IHC), and Western blotting.
Physical and Chemical Properties
CD5 antibodies are typically IgG or IgM immunoglobulins with a molecular weight around 150 kDa for IgG forms. They are supplied as liquid solutions or lyophilized powders, requiring reconstitution in buffers like PBS. Stability depends on storage conditions, with recommended storage at -20°C to prevent degradation. The antibody’s binding affinity is validated through ELISA or similar assays to ensure specificity for the CD5 epitope.
Main Applications
In research, CD5 antibodies are critical for studying T-cell and B1-cell functions, particularly in autoimmune diseases like rheumatoid arthritis and lupus. They are also used in cancer research, as CD5 is expressed in certain lymphomas. Diagnostically, these antibodies aid in identifying CD5+ cell populations in blood or tissue samples, supporting leukemia and lymphoma classification. Some therapeutic antibodies targeting CD5 are under development for immunotherapy.
Safety and Storage
CD5 antibodies should be handled with standard laboratory precautions, including gloves and eye protection. Avoid freeze-thaw cycles, as they can denature the protein. For long-term storage, aliquot the antibody and store at -20°C. Lyophilized formulations may require glycerol addition for stability. Always refer to the manufacturer’s datasheet for specific handling instructions.
B2B Procurement Guide
When procuring CD5 antibodies, prioritize suppliers with validation data (e.g., SDS-PAGE purity, specificity testing). Monoclonal antibodies offer higher consistency but may cost more than polyclonal variants. Consider bulk discounts for large-scale orders, and verify shipping conditions (e.g., cold chain). Leading suppliers include Abcam, BioLegend, and Thermo Fisher Scientific, with prices ranging from $200 to $600 per mg depending on clonality and conjugation.
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