Overview
Carboxyibuprofen is a primary metabolite of ibuprofen, a widely used nonsteroidal anti-inflammatory drug (NSAID). It plays a significant role in the pharmacokinetics and pharmacodynamics of ibuprofen, contributing to its therapeutic effects. As a metabolite, carboxyibuprofen is often studied in clinical and pharmaceutical research to understand drug metabolism and efficacy. Its presence in biological samples is a key indicator of ibuprofen exposure and metabolism in patients.
Physical and Chemical Properties
Carboxyibuprofen is a white to off-white crystalline powder with a molecular weight of 222.28 g/mol. It is soluble in organic solvents such as ethanol but has limited solubility in water. The compound has a melting point of approximately 75-78°C, making it stable under typical storage conditions. Its chemical structure includes a carboxylic acid group, which is responsible for its metabolic activity and interaction with biological systems.
Main Applications
Carboxyibuprofen is primarily used as a pharmaceutical intermediate in the production of ibuprofen and related compounds. It is also a critical metabolite in drug testing and pharmacokinetic studies. In clinical settings, carboxyibuprofen is measured to assess ibuprofen metabolism and dosage optimization. Its role in drug development and testing makes it a valuable compound in the pharmaceutical industry.
Safety and Storage
Carboxyibuprofen should be handled with care to avoid inhalation or direct skin contact. Proper personal protective equipment (PPE), such as gloves and lab coats, is recommended when working with this compound. Storage conditions should include a cool, dry place away from direct sunlight to maintain stability. Proper labeling and containment are essential to prevent accidental exposure or contamination.
B2B Procurement Guide
When procuring carboxyibuprofen, B2B buyers should verify the supplier's compliance with pharmaceutical-grade standards. Certificates of analysis (CoA) and material safety data sheets (MSDS) should be requested to ensure quality and safety. Bulk purchases may offer cost advantages, but buyers should also consider storage and handling requirements. Establishing long-term relationships with reputable suppliers can ensure consistent quality and reliable supply chains.