Overview
Carboxymethyl Dextran (CMD) is a derivative of dextran, a natural polysaccharide produced by bacteria. Through carboxymethylation, dextran gains carboxyl groups, enhancing its water solubility and functionality. This modification makes CMD highly versatile in biomedical applications. CMD is prized for its biocompatibility and biodegradability, aligning with regulatory standards for pharmaceutical and medical uses. Its anionic nature allows it to interact with cationic molecules, facilitating applications like drug encapsulation and diagnostic assays.
Physical and Chemical Properties
CMD is a white, odorless powder that dissolves readily in water, forming clear, viscous solutions. Its viscosity depends on molecular weight and concentration. The carboxymethyl groups introduce negative charges, enabling pH-responsive behavior and ionic interactions. The polymer is stable under dry conditions but hygroscopic, requiring moisture-proof packaging. It degrades under extreme heat or strong acids/bases, limiting its processing conditions. Its hydrogel-forming ability is leveraged in controlled-release systems and wound dressings.
Main Applications
In pharmaceuticals, CMD serves as a drug carrier, improving solubility and prolonging release. It’s used in injectable formulations and oral tablets. Its biocompatibility makes it ideal for tissue engineering scaffolds, supporting cell growth in regenerative medicine. CMD also stabilizes enzymes and antibodies in diagnostic kits. In chromatography, it modifies surfaces to enhance separation efficiency. Industrial uses include coatings and adhesives where biodegradability is prioritized.
Safety and Storage
CMD is non-toxic and non-irritating, classified as GRAS (Generally Recognized As Safe) for specific uses. Dust inhalation should be avoided; PPE like masks is recommended during handling. Store in sealed containers at room temperature, away from humidity. Shelf life typically exceeds two years if stored properly. Avoid contact with oxidizing agents to prevent degradation.
B2B Procurement Guide
Buyers should specify molecular weight (e.g., 70 kDa for drug delivery) and degree of substitution (DS, commonly 0.4–1.0). High-purity grades (>95%) are essential for medical applications. Suppliers may offer bulk discounts for orders exceeding 100 kg. Lead times vary; certified GMP manufacturers are preferred for pharmaceutical-grade CMD. Request COA (Certificate of Analysis) for each batch.
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