Overview
Camptotheca Acuminata Extract is derived from the fruit of the Camptotheca acuminata tree, native to China. The extract is prized for its high concentration of camptothecin, a potent alkaloid with demonstrated anticancer properties. Historically used in traditional Chinese medicine, modern research has validated its efficacy in targeting topoisomerase I, a critical enzyme in DNA replication. In the pharmaceutical industry, this extract serves as a precursor for synthetic derivatives like irinotecan and topotecan, which are FDA-approved for treating colorectal and ovarian cancers. Its demand in B2B markets stems from both clinical and research applications.
Physical and Chemical Properties
The extract typically appears as a light yellow to brown powder, with camptothecin as its primary active component. Camptothecin has a molecular weight of 348.35 g/mol and a melting point of 264-267°C. It is lipophilic, dissolving well in organic solvents such as DMSO and methanol but only marginally in water. Stability is a key concern; the lactone ring in camptothecin can hydrolyze under acidic or alkaline conditions, reducing efficacy. Proper storage (cool, dry, and dark) is essential to maintain potency. Analytical methods like HPLC are used to quantify purity, which often exceeds 98% for pharmaceutical-grade extracts.
Main Applications
The extract's primary application is in oncology, where camptothecin derivatives are used to treat various cancers. Irinotecan and topotecan, semi-synthetic analogs, are frontline therapies for metastatic colorectal cancer and small cell lung cancer, respectively. Beyond pharmaceuticals, the extract is utilized in biochemical research to study topoisomerase inhibition mechanisms. Traditional medicine also employs it for its purported anti-inflammatory and antiviral effects, though these uses lack extensive clinical validation.
Safety and Storage
Due to its toxicity, handling Camptotheca Acuminata Extract requires strict precautions. Personal protective equipment (PPE) such as nitrile gloves, N95 masks, and safety goggles is mandatory. Inhalation or skin contact can cause irritation or systemic effects. Storage recommendations include airtight containers in a freezer (-20°C) for long-term preservation. Short-term storage at room temperature is acceptable if kept desiccated and shielded from light. Stability testing should be conducted periodically to ensure efficacy.
B2B Procurement Guide
When procuring this extract, prioritize suppliers with certifications like GMP or ISO 9001, ensuring quality control. Request certificates of analysis (CoA) detailing purity (HPLC), heavy metal content, and microbial limits. Batch-to-batch consistency is critical for pharmaceutical applications. Negotiate bulk pricing for orders above 100 grams, with reference prices ranging from $100-$500 per gram depending on purity. Consider logistics—cold chain shipping may be necessary to prevent degradation.
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