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Calcium Guanosine Phosphate

Updated: 2026-07-21

Overview

Calcium Guanosine Monophosphate (Ca-GMP) is a calcium salt of guanosine monophosphate, a nucleotide that plays a significant role in various biochemical processes. It is commonly used as a flavor enhancer in the food industry, particularly for its ability to impart umami taste, often synergistically with monosodium glutamate (MSG). In addition to its culinary applications, Ca-GMP serves as a nutritional supplement in pharmaceutical formulations, contributing to nucleotide metabolism. Its stable crystalline form and water solubility make it practical for industrial use.

Physical and Chemical Properties

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Calcium Guanosine Monophosphate appears as a white to off-white crystalline powder with good solubility in water but poor solubility in organic solvents. The compound is relatively stable under normal storage conditions but may decompose upon exposure to extreme heat or prolonged moisture. Its molecular structure includes a guanine base, a ribose sugar, and a phosphate group, with calcium ions providing stability. This configuration contributes to its flavor-enhancing properties and biological activity in metabolic pathways.

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Main Applications

The primary use of Calcium Guanosine Monophosphate is as a flavor enhancer in processed foods, snacks, and seasonings, where it amplifies umami taste. It is often combined with other nucleotides like disodium inosinate to create synergistic flavor effects. In the pharmaceutical industry, Ca-GMP serves as a nucleotide source in clinical nutrition products and supplements. It also finds niche applications in biochemical research and as a precursor in nucleotide synthesis.

Safety and Storage

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Calcium Guanosine Monophosphate is generally recognized as safe when used as a food additive within approved limits. However, excessive consumption may cause minor digestive discomfort in sensitive individuals. For storage, maintain the product in its original sealed container in a cool, dry environment below 25°C. Protect from moisture and direct sunlight to prevent degradation. Standard laboratory safety measures should be followed during handling.

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B2B Procurement Guide

When sourcing Calcium Guanosine Monophosphate, prioritize suppliers that provide certificates of analysis (CoA) verifying purity (typically 98-99%) and confirm the CAS number matches. Food-grade specifications should comply with relevant regulations like FCC or USP standards. Consider ordering in bulk (25kg drums) for cost efficiency if large quantities are needed regularly. For pharmaceutical applications, ensure the supplier can provide documentation meeting GMP requirements. Lead times may vary depending on source location and order volume.

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