Caffeoyltyramine

Updated: 2026-09-09

Overview

Caffeoyltyramine is a naturally occurring phenolic amide derived from the conjugation of caffeic acid and tyramine. It is found in coffee beans, pepper plants, and select medicinal herbs like Cannabis sativa. The compound exhibits notable bioactivity, including antioxidant and anti-inflammatory effects, making it a subject of research in pharmacology and nutrition. Its structural similarity to other hydroxycinnamic acid amides allows it to interact with biological systems, potentially modulating oxidative stress and inflammation pathways. As a secondary metabolite, it contributes to plant defense mechanisms and may offer similar protective benefits in human applications.

Physical and Chemical Properties

Caffeoyltyramine is a crystalline solid with a molecular weight of 299.32 g/mol. It is stable under standard conditions but may degrade under prolonged exposure to light or high temperatures. The compound is soluble in polar organic solvents like methanol and DMSO but has limited solubility in water. Its melting point ranges between 160-165°C, and its UV absorption spectrum shows characteristic peaks at 220 nm and 290 nm, useful for analytical identification. The presence of both phenolic hydroxyl and amide groups contributes to its reactivity, enabling derivatization for enhanced bioavailability or targeted delivery in formulations.

Main Applications

In pharmaceuticals, caffeoyltyramine is explored for its neuroprotective and cardioprotective potential, particularly in mitigating oxidative stress-related diseases. It serves as an intermediate in synthesizing more complex bioactive molecules. The nutraceutical industry incorporates it into supplements for its antioxidant properties, often combined with other polyphenols. In functional foods, it may enhance shelf life and health benefits, though regulatory approval varies by region. Research also investigates its role in cosmetic formulations for anti-aging and skin-protective effects.

Safety and Storage

Caffeoyltyramine is generally regarded as safe at typical doses, with no reported acute toxicity. However, laboratory handling requires standard precautions: use gloves, avoid dust formation, and ensure adequate ventilation. Skin or eye contact should be rinsed immediately with water. For storage, keep the compound in airtight containers under inert gas (e.g., nitrogen) to prevent oxidation. Refrigeration at -20°C is recommended for long-term stability. Degradation products can be monitored via HPLC to ensure quality over time.

B2B Procurement Guide

When sourcing caffeoyltyramine, prioritize suppliers with documented quality control (e.g., COA, HPLC purity ≥95%). Batch-to-batch consistency is critical for industrial applications, so request sample testing before large-scale orders. Pricing varies by purity and quantity, with bulk purchases (100g+) often discounted. Consider suppliers compliant with GMP or ISO standards, especially for pharmaceutical use. Logistics should include temperature-controlled shipping to preserve integrity, and lead times may extend to 4-6 weeks for custom synthesis.