Overview
Bupleurum Extract is a concentrated preparation obtained from the roots of Bupleurum species, primarily used in Traditional Chinese Medicine (TCM). It contains bioactive compounds like saikosaponins (a-d), which account for its therapeutic effects. The extract is standardized to ensure consistent potency, typically containing 10-50% saikosaponins depending on application requirements. Modern pharmacological studies confirm its historical use for treating liver disorders, fever, and inflammatory conditions. Industrial production involves water or ethanol extraction followed by purification steps to remove impurities while retaining active components. It is available as powder, liquid, or soft extract forms.
Physical and Chemical Properties
Bupleurum Extract exhibits hygroscopic properties, requiring careful moisture control during storage. The powder form has a characteristic bitter taste and earthy aroma due to terpenoids and volatile oils. Its solubility profile makes it suitable for aqueous formulations like syrups or injectables. Key quality indicators include saikosaponin concentration (measured via HPLC), residual solvent levels (if ethanol-extracted), and microbial limits. The extract shows stability at pH 4-7 but may degrade under prolonged exposure to high temperatures (>60°C) or UV light. Density measurements help in dosage calculations for liquid formulations.
Main Applications
In pharmaceuticals, Bupleurum Extract is incorporated into liver-protective formulations, often combined with other herbs like licorice or peony. Clinical trials support its use in chronic hepatitis and chemotherapy-induced liver damage. Nutraceutical applications include immune-boosting supplements and anti-stress products. The cosmetic industry utilizes its anti-inflammatory properties in skincare products targeting redness and irritation. Emerging research explores its potential in antiviral therapies, particularly against respiratory viruses. Manufacturers may customize extraction methods to emphasize specific active compounds for targeted applications.
Safety and Storage
While generally recognized as safe, excessive doses may cause dizziness or gastrointestinal discomfort. Regulatory compliance requires testing for pesticides, heavy metals (lead <5 ppm), and aflatoxins. GMP-certified facilities should produce the extract to ensure traceability. Proper storage involves double-layer aluminum bags with desiccants for powders, while liquids need amber glass bottles. Shelf life typically ranges from 18-24 months when stored correctly. Transport should avoid temperature fluctuations, with cold chain recommended for prolonged shipping durations.
B2B Procurement Guide
Buyers should prioritize suppliers providing third-party lab certificates (e.g., ISO 17025 accredited) analyzing saikosaponin profiles and contaminants. MOQs usually start at 5kg for small-scale manufacturers, with bulk discounts available above 100kg. Sample evaluation should include solubility tests and compatibility checks with other formulation ingredients. Contract manufacturing options exist for customized extract ratios or delivery forms (e.g., enteric-coated granules). Payment terms commonly range from 30% advance to LC at sight, with lead times of 2-4 weeks post-order confirmation.
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