Overview
Bufotalin Reference Standard is a highly purified form of bufotalin, a steroidal compound derived from toad venom. It is primarily used as a reference material in pharmaceutical research, quality control, and analytical testing to ensure accuracy and consistency in measurements. This compound is critical for laboratories and pharmaceutical companies that require precise standards for chromatographic analysis, such as HPLC and LC-MS. Its high purity (typically ≥98%) makes it an indispensable tool for method validation and regulatory compliance.
Physical and Chemical Properties
Bufotalin is a white to off-white crystalline powder with a molecular weight of 444.56 g/mol. It has a melting point range of approximately 210-215°C and is soluble in organic solvents like ethanol and methanol, though only slightly soluble in water. The compound's stability is influenced by storage conditions, requiring protection from light and moisture. Its chemical structure includes a steroidal backbone with hydroxyl and carbonyl functional groups, contributing to its biological activity and analytical utility.
Main Applications
The primary use of Bufotalin Reference Standard is in pharmaceutical and biomedical research, where it serves as a calibration standard for analytical techniques like HPLC, LC-MS, and UV spectroscopy. It ensures the accuracy of quantitative and qualitative analyses. Additionally, it is employed in toxicology studies to identify and measure bufotalin in biological samples. Its role in quality control for traditional Chinese medicine (TCM) products, particularly those containing toad venom derivatives, is also significant.
Safety and Storage
Bufotalin is a toxic compound and must be handled with caution. Proper personal protective equipment (PPE), including gloves and lab coats, should be worn to avoid skin contact or inhalation. In case of exposure, seek medical attention immediately. For storage, the compound should be kept in a cool, dry place, ideally at 2-8°C, and protected from light. Proper labeling and secure containers are essential to prevent accidental misuse or contamination.
B2B Procurement Guide
When procuring Bufotalin Reference Standard, prioritize suppliers with a proven track record of providing high-purity chemicals. Verify certificates of analysis (CoA) to confirm purity (≥98%) and check for compliance with regulatory standards such as USP or EP. Price ranges vary based on purity and supplier reliability, typically falling between $200-$500 per gram. Consider bulk purchasing for cost savings, but ensure proper storage facilities are available. Always request safety data sheets (SDS) and shipping conditions to guarantee product integrity.
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