Overview
Bufalin Standard is a purified cardiac glycoside isolated from Ch'an Su (toad venom), used as a certified reference material in analytical laboratories. It serves as a benchmark for quality control in traditional medicine preparations and modern drug discovery. As a biologically active compound, bufalin exhibits potent cytotoxic effects against various cancer cell lines, making it valuable for oncological research. Its standardization ensures reproducibility in pharmacological studies and herbal product testing.
Physical and Chemical Properties
Bufalin crystallizes as a white powder with a characteristic steroidal structure. Its molecular weight of 386.53 g/mol and defined melting point allow for precise identification through thermal analysis. The compound demonstrates limited water solubility but dissolves readily in organic solvents like DMSO, a property critical for in vitro studies. Its UV absorption maxima at 300 nm facilitates HPLC quantification in complex matrices.
Main Applications
In pharmaceutical R&D, bufalin standard enables dose-response studies for its apoptosis-inducing effects in leukemia and solid tumors. Researchers use it to validate anti-cancer mechanisms involving Na+/K+-ATPase inhibition. Traditional medicine manufacturers employ the standard to calibrate analytical methods for toad venom-derived products, ensuring consistent potency. Regulatory bodies reference it when testing for adulteration in herbal supplements.
Safety and Storage
As a toxic compound, bufalin requires strict handling protocols. Laboratories must implement engineering controls (fume hoods) and mandate nitrile gloves, lab coats, and eye protection during preparation. Long-term stability demands storage at -20°C with desiccants to prevent degradation. Amber glass vials minimize photolytic decomposition. Shipping typically requires hazardous material documentation due to its biological activity.
B2B Procurement Guide
Reputable suppliers provide batch-specific certificates detailing purity (HPLC ≥98%), residual solvents, and endotoxin levels. ISO 17025 accreditation ensures traceability to reference standards. Bulk procurement (gram quantities) requires negotiation with specialized fine chemical distributors. Lead times often extend 4-6 weeks for custom purification. Some vendors offer pre-dissolved solutions at defined concentrations for immediate experimental use.
Related Manufacturers
- 主营：[]
- 主营：夹竹桃、异奥卡、香附酮、标准品、儿茶素、白鲜碱、管花苷、紫檀芪、木栓醇、豆甾醇、植酸锌、苏木素、泽泻醇、龙血素、黄柏酮、蚱蜢酮、防己碱、葫芦素、乌甲素、印楝素、厚朴酚、皂苷元、双黄酮、樱桃苷、芝麻素
- 主营：蟾毒灵、桉脂素、化学试剂、β-香树脂酮
- 主营：对照品、标准品
- 主营：桉油精、薄荷脑、白花前胡丙素、标准品、中药对照品、白藜芦醇三甲醚
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、脂蛋白、关基因、亲环素、钾通道、列抗体、ntp溶液、蛋白酶、脑蛋白、病毒抗、蛋白质、239抗体、dtt溶液、科研试剂
- 主营：钩藤碱、丹皮酚、c17h26o10、蟾毒它灵、高良姜、丹参酮、鞣花酸、川楝素、苍术素、芦竹碱、管花苷、苦参碱、土贝母、柚皮素、白麻苷、甜菜碱、紫草素、络石苷、木皂苷、苏木素、甘露糖、番茄碱、青蒿酸、皂苷rg2、芹菜素、紫杉醇
- 主营：千金子、大黄素、紫茎女贞苷b、蟾毒灵、千里光菲灵碱、花青素、甘草系列、水飞蓟系列
- 主营：中间体、天然产物、植物提取物、功能性原料、稀有人参皂苷、淫羊藿、橄榄苦苷、定制、研发、生产
- 主营：三叶苷、姜烯酚、人参皂苷、对照品、标准品、地黄苷、科研试剂、实验室自制、高纯度植物单体、生育三烯酚
- 主营：一叶萩碱、三叶豆紫檀苷、羟基红花黄色素A、精萃宝对照品、苍术素、苍术酮、盐酸血根碱、盐酸白屈菜红碱、药根碱、藁本内酯、欧当归内酯A、高丽槐素、松果菊苷、马钱苷、莫诺苷
- 主营：天然化合物、分析试剂、细胞实验、中药标准品、标准品对照品、标准品、动物实验、中药提取物、单体化合物、科研实验用
- 主营：马齿苋酰胺O、丹参酮、马齿苋酰胺N、蟾毒灵、马齿苋酰胺B、阿魏酸、人参皂苷 RH3、银杏内酯C、岩大戟内酯A、人参皂苷RB2、人参皂苷 Rf、20(S)-人参皂苷、银杏内酯A、桑根酮C、17-羟基岩大戟内酯、橙皮苷、桑根酮D、茶多酚、丹酚酸c、岩大戟内酯B、阿奇霉素、人参皂苷 F1、马齿苋酰胺A、银杏内酯B
- 主营：桤木酮、淫羊藿、皂苷bii、对照品、泽泻醇、香附酮、棕榈碱、羟苯基、半乳糖、山酮iii、甘草酚、侧柏酮、精氨酸、佛尔酮、维生素、管花苷、虫草素、利卡灵、卵磷脂、大豆苷、姜黄素、黄烷酮、半合成、苹果酸、三羟基
- 主营：试液、缓冲液、指示液、分析标准品、质控样品、标准溶液、标准物质、标准样品、滴定液
- 主营：羟基蟾毒灵、白蜡树素、百两金素、半齿泽兰素