Overview
Budesonide is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. It is widely used in pharmaceutical formulations to treat respiratory and gastrointestinal inflammatory conditions. Developed in the 1970s, budesonide has become a cornerstone in managing chronic inflammatory diseases due to its high topical potency and low systemic bioavailability. As a glucocorticoid receptor agonist, budesonide modulates the expression of genes involved in inflammation, reducing symptoms such as swelling, redness, and allergic reactions. Its efficacy and safety profile have made it a preferred choice for inhaled and topical therapies.
Physical and Chemical Properties
Budesonide is a white to off-white crystalline powder with a molecular weight of 430.53 g/mol. It is practically insoluble in water but dissolves well in organic solvents like ethanol, acetone, and chloroform. The compound has a melting point range of 220-228°C, indicating its stability under normal storage conditions. Its chemical structure includes a steroidal backbone with additional functional groups that enhance its binding affinity to glucocorticoid receptors. This structure contributes to its high topical activity and rapid metabolism, minimizing systemic side effects.
Main Applications
Budesonide is primarily used in the treatment of asthma and allergic rhinitis, where it is administered via inhalation to reduce airway inflammation. It is also effective in managing Crohn's disease and ulcerative colitis when delivered as an oral or rectal formulation. In dermatology, budesonide creams and ointments are used to treat inflammatory skin conditions. Its versatility extends to veterinary medicine, where it is used to treat inflammatory conditions in animals. The drug's localized action and minimal systemic absorption make it suitable for long-term use in chronic conditions.
Safety and Storage
Budesonide should be handled with care to avoid inhalation or skin contact. Personal protective equipment, including gloves and masks, is recommended during handling. The compound is stable under recommended storage conditions but should be protected from light and moisture to prevent degradation. In pharmaceutical formulations, budesonide is often combined with other excipients to enhance delivery and stability. Proper storage and handling are critical to maintaining its efficacy and safety profile.
B2B Procurement Guide
When procuring budesonide, B2B buyers should prioritize suppliers with certifications such as GMP (Good Manufacturing Practice) and ISO compliance. Key considerations include verifying the CAS number (51333-22-3), purity (typically ≥98%), and adherence to pharmacopeial standards like USP or EP. Bulk pricing varies based on quantity and supplier, with reference prices ranging from $100 to $500 per kg. Buyers should also assess logistics, including storage and transportation requirements, to ensure product integrity upon delivery.