Overview
β-Bromostyrene (C8H7Br) is an organobromine compound derived from styrene, characterized by a bromine atom attached to the β-carbon of the vinyl group. It is a versatile intermediate in fine chemical synthesis, particularly in pharmaceuticals and agrochemicals. The compound is commercially available as a colorless to pale yellow liquid with a distinct aromatic odor. Its reactivity stems from the labile bromine atom, which facilitates cross-coupling reactions like Heck and Suzuki couplings. Industrial production typically involves bromination of styrene derivatives or dehydrobromination of dibromoethylbenzene. Due to its sensitivity to light and air, it requires careful handling and storage under inert conditions.
Physical and Chemical Properties
β-Bromostyrene has a molecular weight of 183.05 g/mol and a density of 1.41 g/cm³. It boils at 219-221°C but lacks a defined melting point due to its liquid state at room temperature. The compound is hydrophobic, insoluble in water, but miscible with common organic solvents like ethanol, acetone, and dichloromethane. Chemically, it undergoes electrophilic addition and substitution reactions, making it valuable for synthesizing styryl derivatives. Its stability is moderate; prolonged exposure to air or light may cause decomposition, necessitating storage in amber glass containers under nitrogen. Spectroscopic data (IR, NMR) confirm the presence of characteristic vinyl and aromatic proton signals.
Main Applications
In pharmaceuticals, β-bromostyrene serves as a precursor for antipsychotic drugs and anti-inflammatory agents. It is also used to synthesize stilbene derivatives, which exhibit fluorescence properties for optical materials. Agrochemical manufacturers employ it in creating pesticides and herbicides due to its ability to form carbon-carbon bonds with heterocyclic compounds. The compound is equally vital in academic and industrial research for palladium-catalyzed cross-coupling reactions. Recent studies explore its role in polymer chemistry, where it acts as a monomer for functionalized polystyrene copolymers. Specialty chemical producers often customize purity grades (98-99%) to meet specific reaction requirements.
Safety and Storage
β-Bromostyrene is classified as harmful (H302/H315/H319) and requires strict safety measures. Direct contact may cause skin irritation, while inhalation can lead to respiratory distress. Always use nitrile gloves, goggles, and fume hoods during handling. Spills should be neutralized with inert absorbents and disposed of as hazardous waste. Storage demands amber bottles or stainless-steel containers under nitrogen blankets to prevent polymerization. Keep away from oxidizers and heat sources; ideal storage temperature ranges between 2-8°C. Transport regulations typically require UN/NA number labeling (e.g., UN 3082) for international shipping.
B2B Procurement Guide
When sourcing β-bromostyrene, prioritize suppliers with ISO 9001 certification and batch-specific COAs (Certificates of Analysis). Key parameters to verify include purity (≥98%), water content (<0.5%), and residual solvents. For large-scale orders (100+ kg), negotiate bulk discounts but confirm GMP compliance if intended for pharmaceutical use. Sample testing via GC-MS or HPLC is recommended to assess quality. Logistics should ensure temperature-controlled transport, especially for international shipments. Alternative suppliers in China, India, and Europe offer competitive pricing, but audit their production facilities for consistency. MOQs (Minimum Order Quantities) typically start at 25 kg.
Related Manufacturers
- 主营：环戊酮、甲酸镍、阻燃剂、溴苯乙烯、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：硫酸钡、覆盆子酮、胍基丙酸、溴苯乙烯、早强防冻剂、食品级磷酸镁、二肌酸苹果酸、苯基膦酰二氯、食品级硫酸镁、二肌酸柠檬酸
- 主营：石竹素、中间体、邻氟氯苄、偏钒酸钠、油酸甲酯、油酸乙酯、高藜芦胺、氯碘甲烷、反-查耳酮、2-甲基哌嗪、2-糠酸甲酯、2-噻吩甲醛、2-乙基咪唑、四甲酸二酐、2-甲氧基丙烯、萘二甲酰亚胺、8-萘内酰亚胺、2-呋喃甲酸甲酯、4'-联苯二羧酸、对二甲氨基甲苯
- 主营：烷基糖苷APG、氨基磺酸、一水柠檬酸、食品添加剂、表面活性剂
- 主营：均苯四甲酸二酐、芥酸酰胺丙基二甲基叔胺、十一烷、溴苯乙烯、水杨羟肟酸、表面活性剂、中间体、月桂酸钠、十二烷基双羟乙基甲基、肌氨酸钠、苄基胂酸
- 主营：四甲基氢氧化铵、双乙烯酮、环氧环己烷、溴苯乙烯、甲基丙烯酸十八酯、异丙叉丙酮、三聚甲醛、双季戊四醇、均苯四甲酸二酐、十一烷、水杨羟肟酸、硫氢化钠
- 主营：生物活性玻璃、烟酰胺、王浆酸、溴苯乙烯、赖氨酸、锆氟酸、氢化镁
- 主营：医药中间体、香精香料、硅烷偶联剂、苯乙烯磷酸、氧化石蜡皂、苯甲羟肟酸、H205、阻聚剂706、阻聚剂701、萤石矿捕收剂、白钨矿捕收剂、稀土矿捕收剂、氧化锑矿捕收剂、活化剂
- 主营：环氧环己烷、异丙叉丙酮、四甲基氢氧化铵、溴苯乙烯、双乙烯酮、均苯四甲酸二酐、三聚甲醛、氯甲基三氯硅烷、双季戊四醇、五水合四甲基氢氧化铵、月桂酸钠、二苯甲酮、聚硫橡胶、邻氯溴苯、水杨羟肟酸、甲基纤维素、甲基丙烯酸十八酯、氨基磺酸、硫氢化钠、甲基磺酸、吐温、司盘、芥酸pko、pko-e
- 主营：紫胶片、碳酸钠、氮杂双环、溴苯乙烯、n-甲基吡咯烷酮
- 主营：香芹酚、抗氧化增香剂、DCHP、2-咪唑烷酮、对叔戊基苯酚、柠檬烯、五氯硫酚、愈创木酚、邻硝基苯甲醛、二醋酸纤维素、氢化油、硅烷偶联剂、润滑剂、脱模剂、分散剂、消泡剂、阻燃剂、抗氧剂、增塑剂、附着力促进剂、杀菌剂、增稠剂、乳化剂、防老剂、缓蚀阻垢剂
- 主营：甲苯醚、植酸钾、碳酸锶、溴苯乙烯、氟化钙、羟乙基、氟化锰、氟石粉、草酸钴、碳酸钴、27532-96-3、)敏黑tf-、3-氯氯苄、黑色素-1、4-氟氯苄、4-氟苄氯、2-氟苯腈、3-氟苯酚、次黄嘌呤、对氟苄胺、氧化亚镍、氧化亚钴、间氯苯睛、邻氟氯苄、间氟苯腈、无水草酸
- 主营：JP-10、氧化胺、选矿药剂、难选矿活化剂、橡胶助剂、表面活性剂、离子液体、铜萃取剂、碳酸钙抑制剂
- 主营：对二苯甲酸二肼
- 主营：甘氨酸、海藻糖、钙钛矿、氟苯基、油胺碘、硅酸锆、甘油醚、青霉素、状结晶、酒石酸、抗氧剂、钛白粉、凉味剂、晶粉末、硫酸钯、苯乙酮、白色粉、中间体、山梨醇、淡奶油、2-[[(3ar、2-氯烟酸、聚氯乙烯、清澈液体、白色细粉