Overview
β-Bromophenethyl Intermediate is an organobromine compound primarily employed as a building block in organic synthesis. Its reactive bromine moiety makes it valuable for introducing phenethyl groups into target molecules. The compound is widely utilized in pharmaceutical research for constructing active ingredients and in agrochemical production for crop protection agents. As a versatile intermediate, it participates in cross-coupling reactions, nucleophilic substitutions, and serves as a precursor for Grignard reagents. Industrial demand is driven by its role in synthesizing fine chemicals, where precise molecular architecture is critical.
Physical and Chemical Properties
This intermediate exhibits typical alkyl bromide characteristics: a moderate boiling point (220-222°C) and density (1.39 g/cm³). Its solubility profile favors organic solvents like ethanol, diethyl ether, and dichloromethane, while being practically insoluble in water due to its nonpolar aromatic group. The bromine atom at the β-position confers electrophilic reactivity, enabling participation in SN2 reactions. Stability concerns include light sensitivity and potential decomposition under prolonged heat exposure, necessitating amber glass storage and temperature-controlled handling.
Main Applications
In pharmaceuticals, β-Bromophenethyl Intermediate is pivotal for synthesizing β-phenethylamine derivatives, which form the backbone of numerous CNS-active drugs including antidepressants and stimulants. Agrochemical manufacturers employ it to create phenyl-containing pesticides with enhanced bioactivity. The compound also finds niche applications in material science, particularly in modifying polymer side chains to alter thermal or conductive properties. Research laboratories value it for preparing specialized reagents in asymmetric synthesis and metal-catalyzed coupling reactions.
Safety and Storage
As a brominated compound, this intermediate requires strict safety protocols. It is classified as corrosive (Skin Corr. 1B) and causes severe skin burns/eye damage. Always use chemical-resistant gloves (nitrile or neoprene), goggles, and fume hoods during handling. Storage mandates include: tight-sealed containers under inert atmosphere (nitrogen), temperature below 25°C, and segregation from strong oxidizers. Shelf life typically extends to 2 years when properly stored, though discoloration may indicate decomposition. Spill management requires non-combustible absorbents like vermiculite.
B2B Procurement Guide
Industrial buyers should prioritize suppliers with ISO-certified production facilities and comprehensive analytical reports (HPLC, GC-MS). Key specifications to verify include: bromine content (42.5-43.5%), water content (<0.5%), and absence of heavy metal contaminants. Bulk procurement (100kg+) often reduces unit costs by 15-30%. Consider regional logistics—the compound falls under hazardous material shipping regulations (UN 1993). Just-in-time inventory strategies are recommended due to its limited shelf stability. Always audit suppliers for proper storage infrastructure and emergency response capabilities.
Related Manufacturers
- 主营：二甲苯、环保溶剂、丙二醇甲醚、溴苯乙烷、二乙二醇乙醚、涂料成膜助剂
- 主营：防冻液、冰醋酸、乙二醇、溴苯乙烷、冰乙酸、纯吡啶、丙二醇、羟基苯、14丁二醇、3-丙三醇、四氢呋喃、环保乙腈、化工苯酚、1.4丁二醇、医用苯酚、工业苯酚、精制苯酚、价位四氢、乙腈工业、乙酸乙酯、吡啶化工、甲酸乙酯、吡啶工业、求购苯酚、高纯三氯、实验乙腈
- 主营：离子液体、5-二甲基吡唑、咪唑、溴苯乙烷、催化剂、阻燃剂、正丁醇锆、四氟硼酸锂、香兰基丁醚、氟化物、全氟辛基三甲氧基硅烷、丙酮肟、双酚E型氰酸酯、叔丁基乙烯基醚、钯碳催化剂、钛硅分子筛、硫酸烟酰苯胺、丙酮缩氨基硫脲
- 主营：环戊酮、甲酸镍、阻燃剂、溴苯乙烷、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：聚乙二醇、聚丙二醇、叔胺、染料中间体、伯胺
- 主营：溴苯乙烷、对二氧环己酮PDO、聚对二氧环己酮PPDO、乙交酯
- 主营：黄丹粉、柠檬酸、导热油、溴苯乙烷、漂白粉、707乳液、氧化铝、氯化钙、木质素、防腐剂、除锈剂、防锈剂、酒石酸、抗氧剂、松香工业、碳酸氢铵、醋酸铅、碳酸铅
- 主营：5-三甲基己醛、正癸酸、樊多B醛、溴代苯乙烷、聚乙二醇甲醚甲基丙烯酸酯、山梨醇缩水甘油醚、聚苯胺、磷脂酸铵盐、谷胱甘肽、二氧化钒、三羟甲基氨基甲烷盐酸盐、3二羟基萘、二苯酮、庚酰氯、菲尼酮、茶香醇、苹果酸、菠萝醚
- 主营：N-甲基二乙醇胺、丙二醇甲醚、桐油、溴苯乙烷、碳酸丙烯酯、二甲基亚砜、碳酸亚乙烯酯、航空煤油、定制溶剂油、甲基二乙醇胺、270号芳烃溶剂油、副产氯化钾、无水乙醇、溶剂油、甘油、丁二醇
- 主营：P204萃取剂、P507萃取剂、磺化煤油、正十二烷、十二烷基苯、氯代十二烷、白油、磷酸铁、抗氧剂、苯甲醇、聚乙烯亚胺、酒石酸、溶剂油
- 主营：抗氧剂BHT、苯磺酸、苯酚磺酸、环烷酸铈、N235 萃取剂、C272萃取剂、均苯四甲酸二酐、对苯乙烯磺酸钠、氟化铝、椰油酰胺丙基甜菜碱、甘油三苯甲酸酯
- 主营：4-D钠盐、N-甲基硫脲、N-甲基吡咯烷酮、单辛酸甘油酯、N-甲基邻氨基苯甲酸甲酯、三硫代碳酸钠、辛酸镁盐、菜籽油甲酯、8-辛二醇、羟丙基纤维素、硫酸烟酰苯胺、离子液体、咪唑、表面活性剂、光引发剂、紫外线吸收剂、UV单体
- 主营：硫酸铝、硫酸铁、除草剂、农药中间体、医药中间体、芥花籽油、全氟萘烷、桂花精油、乳清酸锂、分析试剂、无色液体、香精香料、淡黄色液体、巯基乙酸钙、化工催化剂、乙酰基六肽、表面活性剂、香料化合物、草酸二水合物、三硫代碳酸钠、二硫氰基甲烷、甲基天冬氨酸、精胺四盐酸盐、苯乙烯化苯酚、硫脲类促进剂
- 主营：溴代吡咯腈、芥酸、异山梨醇、溴苯乙烷、异山梨醇二甲醚、四氯苯醌、对氨基苯乙酸、四乙酰核糖、对氨基苯甲酸、2,6-二氟苯胺、蒽醌
- 主营：化工中间体、生物缓冲剂、实验试剂助剂