Overview
Bromobenzaldehyde, specifically 4-bromobenzaldehyde, is a halogenated aromatic aldehyde. It is a key intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. The compound is characterized by its pale yellow to white crystalline appearance and distinct aromatic odor. Its molecular structure, featuring a bromine atom attached to a benzaldehyde ring, makes it reactive in various chemical transformations. This reactivity is exploited in industries to create complex molecules for medicinal and agricultural applications.
Physical and Chemical Properties
Bromobenzaldehyde has a molecular weight of 185.02 g/mol and a density of 1.48 g/cm³. It melts at 55-58°C and boils at 232-235°C, making it stable under standard conditions. The compound is soluble in common organic solvents like ethanol, ether, and acetone but has limited solubility in water. Its chemical properties include reactivity typical of aromatic aldehydes, such as participation in condensation and nucleophilic addition reactions. The bromine substituent enhances its utility in cross-coupling reactions, which are pivotal in pharmaceutical synthesis.
Main Applications
Bromobenzaldehyde is primarily used in the pharmaceutical industry to synthesize active pharmaceutical ingredients (APIs). It serves as a building block for drugs targeting central nervous system disorders and anti-inflammatory medications. In agrochemicals, it is employed to produce herbicides and pesticides. Additionally, it finds use in dye manufacturing and as a precursor for specialty chemicals, including liquid crystals and photographic developers.
Safety and Storage
Bromobenzaldehyde is an irritant and should be handled with gloves, goggles, and adequate ventilation. Prolonged exposure can cause skin and eye irritation, and inhalation of dust or vapors should be avoided. Store the compound in a cool, dry place, away from direct sunlight and moisture. Sealed containers are recommended to prevent degradation. In case of spills, use inert absorbents and dispose of according to local regulations.
B2B Procurement Guide
When procuring bromobenzaldehyde, prioritize suppliers with certifications like ISO or GMP. Verify the purity (typically 98-99%) through certificates of analysis (CoA). Packaging should be airtight, often in 25 kg drums or smaller containers for laboratory use. Bulk purchases may offer cost savings, but ensure storage capacity aligns with shelf-life considerations. Lead times can vary, so plan orders in advance, especially for customized specifications.
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