Overview
Bromoacetophenone, also known as phenacyl bromide, is an organic compound with the formula C8H7BrO. It is a white to pale yellow crystalline solid widely used as an intermediate in chemical synthesis. The compound is notable for its reactivity due to the presence of a bromine atom, making it valuable in the production of pharmaceuticals and agrochemicals. First synthesized in the late 19th century, bromoacetophenone has become a staple in organic chemistry labs. Its ability to act as an alkylating agent and its role in forming carbon-carbon bonds make it indispensable for researchers and industrial chemists alike.
Physical and Chemical Properties
Bromoacetophenone exhibits a melting point range of 48-51°C and a boiling point of 260-262°C. Its density is approximately 1.647 g/cm³, and it is soluble in common organic solvents such as ethanol, ether, and acetone, though only slightly soluble in water. The compound is stable under normal conditions but should be protected from prolonged exposure to light and moisture to prevent degradation. The bromine atom in bromoacetophenone makes it highly reactive, particularly in nucleophilic substitution reactions. This reactivity is exploited in various synthetic pathways, including the preparation of heterocyclic compounds and other complex organic molecules.
Main Applications
Bromoacetophenone is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It serves as a key building block in the production of anti-inflammatory drugs, antibiotics, and other therapeutic agents. Additionally, it is employed in the manufacture of pesticides and herbicides due to its ability to introduce functional groups into target molecules. In research settings, bromoacetophenone is utilized for its alkylating properties, enabling the formation of carbon-carbon bonds in complex organic syntheses. Its versatility and reactivity make it a valuable tool for chemists working on drug discovery and material science.
Safety and Storage
Bromoacetophenone is classified as an irritant and can cause skin and eye irritation upon contact. Proper handling procedures, including the use of gloves, goggles, and lab coats, are essential to minimize exposure. In case of contact, affected areas should be rinsed immediately with plenty of water. Storage recommendations include keeping the compound in a cool, dry place away from direct sunlight and moisture. It should be stored in airtight containers to prevent degradation. Proper labeling and segregation from incompatible substances, such as strong oxidizing agents, are also critical to ensure safety.
B2B Procurement Guide
When procuring bromoacetophenone, buyers should prioritize suppliers with a proven track record of quality and reliability. Key considerations include verifying the purity of the compound, which is typically available in grades ranging from 95% to 99%. Certificates of analysis (CoA) should be requested to confirm specifications. Bulk purchasing can lead to significant cost savings, with prices commonly ranging from $50 to $100 per kilogram. Buyers should also assess logistics and storage capabilities to ensure the compound remains in optimal condition during transit and upon receipt. Establishing long-term supplier relationships can further enhance procurement efficiency.
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