Overview
Bromo-4-nitroacetophenone is a brominated derivative of nitroacetophenone, commonly used as a chemical intermediate in various industries. It is particularly valued in pharmaceutical and agrochemical manufacturing for its role in synthesizing active ingredients. The compound is known for its stability and reactivity, making it a versatile building block in organic chemistry. Its synthesis typically involves the bromination of 4-nitroacetophenone, resulting in a product with high purity and consistent quality. Due to its specialized applications, Bromo-4-nitroacetophenone is primarily traded in B2B markets, with suppliers catering to industrial needs.
Physical and Chemical Properties
Bromo-4-nitroacetophenone appears as a light yellow to yellow crystalline powder with a molecular weight of 244.04 g/mol. It has a melting point range of 98-102°C and is soluble in common organic solvents such as ethanol and acetone, though it exhibits limited solubility in water. The compound is stable under standard conditions but can react with strong oxidizing agents, necessitating careful handling. Its bromine and nitro functional groups contribute to its reactivity, enabling its use in various substitution and condensation reactions in synthetic chemistry.
Main Applications
Bromo-4-nitroacetophenone serves as a critical intermediate in the pharmaceutical industry, where it is used to synthesize drugs targeting various therapeutic areas. Its reactivity makes it suitable for constructing complex molecular frameworks in agrochemicals, including herbicides and insecticides. In organic synthesis, the compound is employed in the preparation of dyes, fragrances, and other specialty chemicals. Its versatility and reliability have established it as a staple in research and industrial laboratories, particularly in reactions requiring brominated aromatic compounds.
Safety and Storage
Bromo-4-nitroacetophenone requires careful handling due to its potential to irritate skin and eyes. Proper personal protective equipment (PPE), including gloves and goggles, should be worn when working with this chemical. A fume hood is recommended to minimize inhalation risks. Storage should be in a cool, dry, and well-ventilated area, away from heat sources and direct sunlight. Containers must be tightly sealed to prevent moisture absorption and contamination. Incompatible materials include strong oxidizing agents, which should be stored separately to avoid hazardous reactions.
B2B Procurement Guide
When procuring Bromo-4-nitroacetophenone, buyers should prioritize suppliers with verified certifications and a track record of delivering high-purity products. Key considerations include the CAS number (99-81-0), purity levels (typically 98% or higher), and packaging options tailored to industrial needs. Bulk purchases often benefit from discounted pricing, with reference prices ranging from $50 to $100 per kg. Procurement professionals should also assess logistical factors, such as storage requirements and transportation conditions, to ensure product integrity upon delivery. Reliable suppliers will provide material safety data sheets (MSDS) and technical support as needed.
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