Overview
α-Bromo-m-nitroacetophenone is an organic compound widely used as an intermediate in pharmaceutical and agrochemical synthesis. Its reactive bromo and nitro groups make it valuable for constructing complex molecules. The compound is typically supplied as a crystalline powder and requires careful handling due to its irritant properties. In industrial settings, it is often employed in multi-step synthesis processes to produce active pharmaceutical ingredients (APIs) or specialty chemicals. Its stability under controlled conditions and predictable reactivity profile contribute to its utility in research and manufacturing.
Physical and Chemical Properties
This compound appears as a pale yellow to yellow crystalline solid with a molecular weight of 244.04 g/mol. It has a melting point range of 80-85°C and dissolves readily in common organic solvents like ethanol and acetone, though it has limited solubility in water. The presence of both bromo and nitro substituents on the acetophenone backbone makes it highly reactive in substitution and condensation reactions. These functional groups allow it to participate in nucleophilic aromatic substitution (SNAr) and other key transformations in synthetic chemistry.
Main Applications
α-Bromo-m-nitroacetophenone serves as a crucial building block in pharmaceutical synthesis, particularly for drugs containing nitrophenyl or bromophenyl moieties. It is frequently used to produce intermediates for antibiotics, anti-inflammatory agents, and central nervous system drugs. In agrochemical production, the compound contributes to the synthesis of certain pesticides and herbicides. Its reactivity also makes it valuable in academic and industrial research settings for developing novel organic compounds and studying reaction mechanisms.
Safety and Storage
As a reactive chemical, α-Bromo-m-nitroacetophenone requires strict safety measures. It is classified as an irritant and can cause skin, eye, and respiratory tract irritation. Always use personal protective equipment (PPE) including gloves, goggles, and lab coats when handling this material. For storage, keep the compound in tightly sealed containers in a cool, dry place away from direct sunlight and moisture. Incompatible with strong oxidizers and bases, it should be segregated from these materials. Proper ventilation is essential in working areas to prevent vapor accumulation.
B2B Procurement Guide
When procuring α-Bromo-m-nitroacetophenone, prioritize suppliers with documented quality control processes and proper chemical handling certifications. Key specifications to verify include purity (typically 97-99%), CAS number confirmation (14548-38-0), and batch-to-batch consistency. Request material safety data sheets (MSDS) and certificates of analysis (CoA) before purchase. For large-volume orders, consider arranging sample testing. Price negotiation is common for quantities above 100kg, with bulk discounts typically available. Evaluate supplier logistics capabilities to ensure proper hazardous material transportation compliance.
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