Overview
Bicalutamide is a widely used non-steroidal anti-androgen (NSAA) that plays a critical role in the treatment of prostate cancer. It functions by competitively inhibiting androgen receptors, thereby preventing the growth-stimulating effects of androgens on prostate cancer cells. Bicalutamide is often administered in combination with other treatments, such as luteinizing hormone-releasing hormone (LHRH) analogs, to enhance therapeutic outcomes. First approved for medical use in the 1990s, bicalutamide has since become a staple in oncology due to its efficacy and relatively manageable side-effect profile. It is available under various brand names, including Casodex, and is typically prescribed in oral tablet form.
Physical and Chemical Properties
Bicalutamide is a white to off-white crystalline powder with a molecular weight of 430.37 g/mol. Its molecular formula is C18H14F4N2O4S, indicating the presence of fluorine and sulfur atoms, which contribute to its biological activity. The compound has a melting point of approximately 193-195°C and is slightly soluble in water but more soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO). These properties make bicalutamide suitable for formulation into oral tablets and other pharmaceutical preparations. Its stability under standard storage conditions (room temperature, protected from light and moisture) ensures a long shelf life when handled correctly.
Main Applications
The primary application of bicalutamide is in the treatment of prostate cancer, particularly in cases where the cancer is hormone-sensitive. It is often used in combination with surgical or medical castration to achieve maximal androgen blockade (MAB). This approach helps to delay disease progression and improve patient survival rates. In addition to its use in prostate cancer, bicalutamide has been explored for other conditions involving androgen excess, such as hirsutism and acne in women. However, its use in these areas remains off-label and is less common compared to its well-established role in oncology.
Safety and Storage
Bicalutamide should be handled with care to avoid skin or eye contact, as it may cause irritation. Personnel working with the compound should use appropriate protective equipment, including gloves and safety glasses. In case of exposure, affected areas should be rinsed thoroughly with water. For storage, bicalutamide should be kept in a cool, dry place at room temperature, away from direct light and moisture. Properly sealed containers are essential to maintain the compound's stability and prevent degradation. Bulk quantities should be stored in compliance with pharmaceutical industry standards to ensure quality and safety.
B2B Procurement Guide
When procuring bicalutamide for B2B purposes, it is crucial to verify the supplier's compliance with Good Manufacturing Practices (GMP) and other relevant pharmaceutical standards. The CAS number (90357-06-5) should be confirmed to ensure the correct compound is being purchased. Purity levels, typically 98% or higher for pharmaceutical use, must also be specified. Price ranges for bicalutamide can vary significantly depending on the quantity and supplier. Bulk purchases may offer cost advantages, but buyers should balance this with the need for reliable quality control. Establishing long-term relationships with reputable suppliers can help ensure consistent quality and timely delivery.
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