Overview
Bifunctional PEG refers to polyethylene glycol derivatives with two distinct reactive end groups, enabling precise conjugation in pharmaceuticals and biomaterials. These small-molecule linkers (typically <10 kDa) bridge molecules like proteins, drugs, or nanoparticles while improving solubility and pharmacokinetics. Unlike monofunctional PEG, bifunctional variants offer controlled crosslinking or sequential modifications. Their modular design supports applications from antibody-drug conjugates (ADCs) to 3D cell culture scaffolds. The global market is driven by demand for targeted therapies and advanced drug delivery systems.
Physical and Chemical Properties
Bifunctional PEG exhibits high water solubility due to its ethylene oxide backbone, with properties adjustable via chain length (n-value). Common end groups include amines (-NH₂), carboxyls (-COOH), and maleimide, each enabling specific reactions like amide bond formation or thiol coupling. The compound’s low polydispersity (PDI <1.05 for high-grade) ensures consistent performance. Thermal stability varies by molecular weight, with degradation above 250°C. Viscosity increases exponentially with chain length, impacting handling in industrial processes.
Main Applications
In biopharmaceuticals, bifunctional PEG links payloads to targeting antibodies, as seen in ADC therapies like Adcetris®. It also prolongs drug half-life by shielding molecules from immune detection (PEGylation). Material science utilizes it for synthesizing hydrogels with controlled degradation rates. Other uses include surface PEGylation of medical devices to prevent fouling and as spacers in diagnostic assays to reduce steric hindrance.
Safety and Storage
While generally safe, powder forms may irritate respiratory tracts—use PPE during handling. Store under inert gas (e.g., argon) for long-term stability, especially for moisture-sensitive derivatives like NHS esters. Dispose via incineration or approved chemical waste channels. Regulatory status varies by application; pharmaceutical-grade PEG must comply with USP/EP monographs for endotoxin levels (<5 EU/mg).
B2B Procurement Guide
Key specifications include molecular weight (e.g., 1kDa, 5kDa), end-group purity (>95%), and absence of diols (verified by HPLC). Bulk buyers should request batch-specific COAs and stability data. Leading manufacturers (e.g., JenKem Technology, Creative PEGWorks) offer custom functionalization. Prices scale inversely with quantity; negotiate volume discounts for orders >1kg. Consider supply chain stability—PEG production is energy-intensive and affected by ethylene oxide availability.
Related Manufacturers
- 主营：在水中、包含肽、含叠氮、peg单元、peg试剂、aminopeg8、丙炔基、由氨基、菁染料、具有炔、胺hcl盐、阿尔法、催化剂、结构式、氨基nh2、3694-51-7、碘化物、4727-50-8、具有两、带有炔、磺酸基、3065-79-0、甲基九、bcn基团、荧光素
- 主营：白矿油、10号白油、15号白油、26号白油、32号白油、石蜡基油、橡胶油、环烷油、黄油、超细白炭黑、白炭黑、促进剂、环保颗粒助剂、防老剂、增塑剂、氧化锌、硬脂酸、3L标胶、高苯橡胶、丁二烯橡胶、消光粉、超细二氧化硅、天然橡胶
- 主营：二丙二醇、二甘醇、甲基丙二醇、异辛醇、片碱、草酸、氢氧化钾、氨基磺酸、三羟甲基丙烷
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、双PEG、10-羟基癸酸、苯乙烯磷酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、乙烯基磷酸二乙酯、磷酸锰铁锂、β-磷酸三钙、十一烯酸、钨酸铝、1-乙炔基环已醇、间二异丙苯、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：抗氧剂、乳化剂、苯扎氯铵、双链季胺盐、烷基二甲基、氢化蓖麻油、表面活性剂、聚氧乙烯醚、二丁基羟基甲苯、甘油聚氧丙烯醚、十二烷基硫酸钠、树脂、助剂
- 主营：固体酸催化剂、重组胶原蛋白、硅油、特种硅油、聚硅氮烷、硼酸铝晶须、碳化硅晶须、t-BAMBP萃取剂、全氟三丁胺
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：异辛醇、乳化剂、乙烯醚、醚羧酸、脂肪醇、分散剂、染色助剂、聚乙二醇、异构醇醚、泊洛沙姆、椰油酰胺、基羟乙基、烷基糖苷、特辛基酚、聚氧乙烯、嵌段聚醚、单油酸酯、异构十三醇、丙烯磺酸钠、氢化蓖麻油、丙烯酰胺基、醇醚葡糖苷、低泡渗透剂、甲酯乙氧基、癸基葡糖苷
- 主营：叔碳酸、十八醛、溶菌酶、双PEG、海藻糖、癸二醇、氨基丙基、氢路噻嗪、邻苯二甲、乙基碳二、羟基癸酸、正十七烷、谷胱甘肽、烷二甲醇、松果体素、vc磷酸酯镁、2-甲基丁醛、朱栾倍半萜、丁烷四乙酸、表面活性剂、癸烷撑二醇、缩水甘油邻、10-羟基羊蜡酸、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：二氧化硅、乳化剂、消泡剂、分散剂、润湿剂、增稠剂、树脂、抗氧剂、杀菌防腐防霉剂、uv单体
- 主营：全氟三丁胺、木质素、吉氏色素
- 主营：磷酸三甲苯酯、氨基甲酸乙酯、磷酸甲苯二苯酯、甲乙酮肟、四乙基溴化铵、碳酸二丁酯、环烷酸铅、亚硫酸铵、二苯甲酮腙、石油磺酸钠、三乙醇胺、甲醇、乙醇、二甲苯、二氯甲烷、环烷酸铜、氨基甲酸甲酯、单过硫酸氢钾、氯化石蜡、三异丙醇胺、苄基三甲基氯化铵、苄基三乙基氯化铵、四乙基氯化铵、四甲基氯化铵、新癸酸铋
- 主营：阻燃剂、拉那白、牛儿酮、海藻糖、热敏蓝、萘磺酸、氯菊酯、硫酸锌、催化剂、杨梅酯、檀香醚、聚醚胺、吸收剂、脂檀油、苍术素、羟钴胺、转移剂、溶剂绿、麝香酮、王浆酸、芬多精、纤维素、新戊酯、王冠醚、遮甜粉
- 主营：低泡聚醚SF、MOA3B聚醚消泡剂、甘油醚聚氧丙烯醚GP、双油酸酯400DO、磷酸酯MOA7P、磷酸酯MOA3P、异构13醇磷酸酯、司盘S-80、MPEG2000、聚乙二醇600、司盘S-20、吐温T-20、吐温60、吐温81、吐温T85、石蜡乳化剂、白油乳化剂163、滲透剂JFC、滲透剂OE-35、滲透剂AEP、添加剂AC1210、聚醚L-64
- 主营：18908-66-2、癸甲氯铵、咪唑烷酮、二异丁腈、饲料添加剂、分散剂工业、柠檬酸三丁酯、聚乙烯吡咯烷、二甲基溴化铵
- 主营：三甘醇、五氧化二钒、纯牛骨蛋白胨、牛油脂肪酸、氯偏乳液、苄基胂酸、漂粉精、苯甲醇、草酸镍、磷酸、六氟磷酸钾、次氯酸钙、钯碳、草酸钛钾、粘土固化剂、福美钠、戊二醛、碳酸钡、硝酸异辛酯、二甲基二硫代氨基甲酸、四氧化三铅、氯化锌、松醇油、磺化油、氟化氢钾