Bifonazole

Updated: 2026-09-16

Overview

Bifonazole is a synthetic imidazole antifungal agent widely used in the treatment of superficial fungal infections. It is particularly effective against dermatophytes, yeasts, and molds. The compound was first introduced in the 1980s and has since become a staple in antifungal therapies due to its efficacy and safety profile. Bifonazole is commonly formulated as creams, ointments, and solutions for topical application. Its mechanism of action involves inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, thereby disrupting fungal growth and replication.

Physical and Chemical Properties

Bifonazole is a white to off-white crystalline powder with a molecular weight of 310.39 g/mol. It has a melting point of approximately 147-149°C and is soluble in organic solvents like ethanol, though it is only slightly soluble in water. These properties make it suitable for formulation in various topical preparations. The compound's stability is maintained under recommended storage conditions, which include protection from light and moisture. Its chemical structure includes an imidazole ring, which is responsible for its antifungal activity by targeting fungal cytochrome P450 enzymes.

Main Applications

Bifonazole is primarily used to treat fungal skin infections, including athlete's foot (tinea pedis), ringworm (tinea corporis), and yeast infections (candidiasis). It is also effective against seborrheic dermatitis and other dermatomycoses. The medication is typically applied once daily, with treatment duration varying based on the infection's severity. In addition to its medical uses, bifonazole is sometimes employed in veterinary medicine to treat fungal infections in animals. Its broad-spectrum activity and low incidence of side effects make it a versatile choice for both human and animal healthcare.

Safety and Storage

Bifonazole is generally safe for topical use, but precautions should be taken to avoid contact with eyes and mucous membranes. In case of accidental exposure, rinse thoroughly with water. The compound should be stored in a cool, dry place, away from direct sunlight and moisture, to maintain its stability and efficacy. Although adverse reactions are rare, some individuals may experience localized irritation, redness, or itching. Discontinue use if severe reactions occur and consult a healthcare professional. Bifonazole is not recommended for use in individuals with known hypersensitivity to imidazole antifungals.

B2B Procurement Guide

When procuring bifonazole, it is essential to verify the supplier's credentials and ensure compliance with pharmaceutical standards. Key factors to consider include the compound's purity, CAS number (60628-96-8), and packaging specifications. Bulk purchases may offer cost advantages, but quality should never be compromised. Procurement professionals should also consider the supplier's ability to provide certificates of analysis (CoA) and material safety data sheets (MSDS). Establishing long-term relationships with reputable suppliers can ensure consistent quality and reliable delivery schedules.