Bicalutamide[2]
Overview
Bicalutamide is a non-steroidal anti-androgen drug primarily used in the treatment of prostate cancer. It was first approved for medical use in the 1990s and has since become a standard treatment option. The drug works by competitively inhibiting androgen receptors, thereby blocking the effects of testosterone and dihydrotestosterone (DHT), which are known to promote the growth of prostate cancer cells. Bicalutamide is typically administered orally and is often used in combination with other treatments such as surgical castration or gonadotropin-releasing hormone (GnRH) analogues. Its effectiveness and relatively manageable side effect profile have made it a popular choice among oncologists and patients alike.
Physical and Chemical Properties
Bicalutamide is a white to off-white crystalline powder with a molecular weight of 430.37 g/mol. Its molecular formula is C18H14F4N2O4S, and it has a melting point of 191-193 °C. The drug is slightly soluble in water but exhibits better solubility in organic solvents such as methanol and ethanol. The compound's stability is influenced by environmental factors like light and moisture, necessitating proper storage conditions. Bicalutamide's chemical structure includes a sulfonyl group and a fluorine-substituted aromatic ring, which contribute to its high affinity for androgen receptors and its efficacy in blocking androgen signaling pathways.
Main Applications
The primary application of bicalutamide is in the treatment of prostate cancer, particularly in cases where the cancer is hormone-sensitive. It is often prescribed as part of combined androgen blockade (CAB) therapy, where it is used alongside surgical castration or GnRH analogues to maximize the suppression of androgen activity. In addition to its use in prostate cancer, bicalutamide has been investigated for potential applications in other androgen-dependent conditions, such as hirsutism and acne. However, its use in these areas remains off-label and is not as well-established as its role in prostate cancer treatment.
Safety and Storage
Bicalutamide is generally well-tolerated, but it can cause side effects such as hot flashes, fatigue, gynecomastia, and liver toxicity. Patients with pre-existing liver conditions should be monitored closely, as the drug can elevate liver enzymes and, in rare cases, lead to severe liver damage. Proper storage of bicalutamide is essential to maintain its efficacy. The drug should be kept at room temperature, away from direct light and moisture. It is also important to store it out of reach of children and pets, as accidental ingestion can lead to serious health risks.
B2B Procurement Guide
When procuring bicalutamide for B2B purposes, it is crucial to verify the supplier's credentials and ensure compliance with pharmaceutical regulations. The drug is subject to strict quality control standards, and buyers should request certificates of analysis (CoA) and good manufacturing practice (GMP) certifications from suppliers. The reference price for bicalutamide varies depending on the dosage form and quantity purchased. Generally, prices range from approximately $50 to $200 per 50mg tablet. Bulk purchases may offer cost savings, but buyers should also consider factors like shipping conditions, lead times, and the reliability of the supply chain.