Overview
BGB-290, also known as Pamiparib, is a potent and selective PARP (Poly ADP-ribose polymerase) inhibitor. It is primarily used in the treatment of cancers with homologous recombination deficiencies, such as BRCA-mutated tumors. Developed by BeiGene, BGB-290 has shown promise in clinical trials for its efficacy and manageable safety profile. PARP inhibitors like BGB-290 work by blocking the enzyme PARP, which plays a critical role in DNA repair. By inhibiting PARP, cancer cells with defective DNA repair mechanisms are unable to survive, leading to targeted cell death. This makes BGB-290 a valuable tool in precision oncology.
Physical and Chemical Properties
BGB-290 is a white to off-white solid with a molecular weight of 356.4 g/mol. Its molecular formula is C18H21FN6O, indicating the presence of fluorine and nitrogen, which contribute to its pharmacological activity. The compound is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in water. Storage conditions for BGB-290 recommend keeping it at -20°C in a dry, dark place to maintain stability. The compound's high selectivity and oral bioavailability make it suitable for clinical use, though handling requires precautions to avoid exposure.
Main Applications
BGB-290 is primarily used in the treatment of cancers with homologous recombination deficiencies, such as ovarian, breast, and prostate cancers with BRCA mutations. It is often administered as part of combination therapies or as a monotherapy in advanced stages of the disease. Clinical trials have demonstrated its efficacy in extending progression-free survival in patients with recurrent ovarian cancer. Its ability to cross the blood-brain barrier also makes it a candidate for treating brain metastases, though further research is ongoing.
Safety and Storage
BGB-290 should be handled with care, using appropriate personal protective equipment (PPE) such as gloves and lab coats. Avoid inhalation or direct contact with skin and eyes, as it may cause irritation. Follow GHS (Globally Harmonized System) guidelines for safe handling and disposal. Storage conditions are critical for maintaining the compound's stability. It should be stored at -20°C in a tightly sealed container, protected from light and moisture. Long-term stability data should be reviewed before use in large-scale applications.
B2B Procurement Guide
When procuring BGB-290, buyers should verify the supplier's credentials and request a Certificate of Analysis (COA) to ensure purity and quality. Stability data and storage recommendations should also be provided to ensure the compound's efficacy upon delivery. Prices for BGB-290 can vary significantly depending on quantity and supplier. Bulk purchases may offer cost savings, but buyers should balance this with storage capabilities and usage rates to avoid waste. Always work with reputable suppliers to mitigate risks associated with counterfeit or substandard products.
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