Overview
Benzoylecgonine is a major metabolite of cocaine, produced when the body breaks down the drug. It is widely recognized in toxicology and forensic science as a reliable biomarker for cocaine use due to its stability and detectability in biological samples. Unlike cocaine, benzoylecgonine does not produce psychoactive effects, making it an important compound for diagnostic and research purposes. The compound was first identified in the early 20th century as part of studies on cocaine metabolism. Today, it plays a crucial role in drug testing programs, workplace screenings, and medical diagnostics. Its presence in urine, blood, or hair samples can indicate cocaine consumption, even days after use.
Physical and Chemical Properties
Benzoylecgonine is a white crystalline powder with a molecular weight of 289.33 g/mol. It is soluble in water and alcohol, which facilitates its detection in liquid biological samples. The compound has a melting point of approximately 195-196°C, and its stability under normal conditions makes it suitable for long-term storage. Chemically, benzoylecgonine is an ester of ecgonine and benzoic acid. Its structure includes a tropane ring, which is characteristic of many alkaloids. The compound is non-volatile and does not degrade easily, which contributes to its reliability as a biomarker in forensic and medical testing.
Main Applications
The primary application of benzoylecgonine is in forensic and medical testing. It is the target compound in urine drug tests for cocaine, as it remains detectable longer than cocaine itself. Laboratories use techniques like gas chromatography-mass spectrometry (GC-MS) to identify and quantify benzoylecgonine in samples. In addition to drug testing, benzoylecgonine is used in pharmaceutical research to study cocaine metabolism and develop treatments for cocaine addiction. Its role in toxicology studies helps understand the long-term effects of cocaine use on the human body.
Safety and Storage
While benzoylecgonine is not psychoactive, it should be handled with care in laboratory settings. Avoid ingestion, inhalation, or skin contact, as it may cause irritation or other adverse effects. Proper personal protective equipment (PPE), such as gloves and lab coats, should be worn when handling the compound. Storage conditions are critical to maintaining the integrity of benzoylecgonine. It should be kept in a cool, dry place, away from direct light and moisture. Sealed containers are recommended to prevent contamination or degradation over time.
B2B Procurement Guide
Procuring benzoylecgonine requires adherence to strict regulatory guidelines, as it is a controlled substance in many jurisdictions. Buyers should verify the legal status of the compound in their region before purchasing. Reputable suppliers with proper certifications should be prioritized to ensure product quality and compliance. When sourcing benzoylecgonine, consider the intended use—whether for research, forensic testing, or pharmaceutical development. Bulk purchases may offer cost advantages, but storage and handling capabilities should be assessed. Always request certificates of analysis (CoA) to confirm purity and composition.
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