Overview
Barnidipine is a dihydropyridine calcium channel blocker primarily used in the treatment of hypertension. It works by selectively inhibiting calcium ion influx into vascular smooth muscle cells, leading to vasodilation and reduced blood pressure. Developed as an antihypertensive agent, it is known for its long-lasting effects and relatively mild side-effect profile compared to other calcium channel blockers. Barnidipine is marketed under various brand names worldwide and is commonly prescribed for patients with essential hypertension. Its efficacy and safety have been demonstrated in clinical trials, making it a reliable option for long-term management of high blood pressure.
Physical and Chemical Properties
Barnidipine is a white to light yellow crystalline powder with a molecular weight of 482.57 g/mol. It is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO) but has poor solubility in water. The compound has a melting point of approximately 140-142°C, which is typical for dihydropyridine derivatives. Its chemical stability is influenced by environmental factors such as light and moisture, necessitating proper storage conditions. The molecular structure of barnidipine includes a dihydropyridine ring, which is essential for its calcium channel-blocking activity.
Main Applications
Barnidipine is primarily used in the treatment of hypertension (high blood pressure) and angina pectoris. By blocking calcium channels in vascular smooth muscle, it reduces peripheral vascular resistance and lowers blood pressure without significantly affecting heart rate. This makes it particularly suitable for patients with coexisting conditions such as diabetes or renal impairment. In addition to its antihypertensive effects, barnidipine has been studied for potential benefits in other cardiovascular conditions. However, its primary use remains focused on managing hypertension, often as part of a combination therapy regimen.
Safety and Storage
Barnidipine should be stored in a cool, dry place, protected from light and moisture to maintain its stability. Improper storage can lead to degradation, reducing its efficacy. When handling the compound, appropriate personal protective equipment (PPE) such as gloves and masks should be used to avoid inhalation or direct contact. As a pharmaceutical agent, barnidipine is generally well-tolerated, but side effects such as dizziness, headache, and peripheral edema may occur. Patients with severe liver impairment or hypersensitivity to dihydropyridines should use it with caution.
B2B Procurement Guide
When procuring barnidipine for B2B purposes, it is essential to verify the supplier's compliance with pharmaceutical-grade standards and regulatory requirements. Key considerations include the compound's purity, batch consistency, and documentation such as Certificates of Analysis (CoA). Prices may vary depending on the quantity and supplier, so obtaining multiple quotes is advisable. Additionally, ensure that the supplier has a reliable track record in delivering high-quality pharmaceutical raw materials to avoid potential disruptions in production.
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