Baicalin

Updated: 2026-08-06

Overview

Baicalin is a bioactive flavonoid extracted from the roots of Scutellaria baicalensis, a plant widely used in traditional Chinese medicine. It is known for its therapeutic properties, including anti-inflammatory, antioxidant, and antimicrobial effects. The compound has garnered attention in modern pharmacology for its potential in treating conditions like hepatitis, allergies, and cardiovascular diseases. Baicalin’s chemical structure includes a glucuronide moiety, which enhances its solubility and bioavailability. Research suggests it modulates immune responses and inhibits oxidative stress, making it a promising candidate for drug development and nutraceuticals.

Physical and Chemical Properties

Baicalin appears as a yellow crystalline powder with a melting point range of 223–227°C. It is soluble in organic solvents like methanol and ethanol but has limited solubility in water. The molecular weight is 446.36 g/mol, and its stability is influenced by pH, temperature, and light exposure. Key chemical properties include its ability to chelate metal ions and scavenge free radicals, contributing to its antioxidant activity. The compound’s UV absorption spectrum (λmax ~277 nm and ~315 nm) is often used for qualitative and quantitative analysis in laboratories.

Main Applications

In pharmaceuticals, baicalin is studied for its role in treating inflammatory diseases, liver disorders, and viral infections. It is a common ingredient in herbal supplements aimed at boosting immunity and reducing oxidative stress. The cosmetics industry utilizes baicalin for its anti-aging and skin-soothing properties. It is incorporated into serums, creams, and sunscreens to protect against UV-induced damage. Additionally, baicalin is used in veterinary medicine to manage animal health conditions.

Safety and Storage

Baicalin is generally safe when used in recommended doses. However, excessive intake may cause gastrointestinal discomfort. Proper storage in airtight containers, away from light and moisture, is essential to maintain its stability. Handling should follow standard laboratory safety protocols, including the use of gloves and goggles. Refer to the material safety data sheet (MSDS) for specific hazard information and first-aid measures in case of accidental exposure.

B2B Procurement Guide

When procuring baicalin, prioritize suppliers with certifications such as GMP or ISO 9001. Request certificates of analysis (CoA) to verify purity (typically ≥98% by HPLC) and check for contaminants like heavy metals or residual solvents. Bulk purchases often offer cost advantages, but ensure the supplier provides proper packaging (e.g., aluminum foil bags) to prevent degradation. Sample testing before large orders is advisable to confirm consistency and compliance with specifications.