Overview
Baicalein is a bioactive flavonoid extracted from the roots of Scutellaria baicalensis, commonly known as Chinese skullcap. It has been used in traditional Chinese medicine for centuries due to its therapeutic properties. Modern research highlights its potential in treating inflammatory diseases, cancer, and neurodegenerative disorders. As a natural compound, baicalein is increasingly sought after in the pharmaceutical and nutraceutical industries. Its ability to modulate oxidative stress and inflammation makes it a promising candidate for drug development and health supplements.
Physical and Chemical Properties
Baicalein appears as a yellow crystalline powder with a molecular weight of 270.24 g/mol. It has a melting point of 264-265°C and is soluble in organic solvents like ethanol and DMSO, but only slightly soluble in water. The compound's chemical structure includes three hydroxyl groups, which contribute to its antioxidant activity. Its stability under normal storage conditions makes it suitable for long-term use in various formulations, provided it is protected from light and moisture.
Main Applications
Baicalein is widely used in pharmaceuticals for its anti-inflammatory and anticancer effects. It inhibits enzymes like COX-2 and 5-LOX, reducing inflammation. Studies also suggest it induces apoptosis in cancer cells, making it a potential adjunct therapy. In the nutraceutical industry, baicalein is incorporated into dietary supplements for its antioxidant benefits. Additionally, its neuroprotective properties are being explored for treating Alzheimer's and Parkinson's diseases. Cosmetic formulations use it for its skin-soothing and anti-aging effects.
Safety and Storage
Baicalein is generally considered safe at recommended doses, but excessive intake may cause gastrointestinal discomfort. Proper handling includes wearing gloves and avoiding inhalation of dust. Storage should be in a cool, dry place, away from direct sunlight and moisture. Sealed containers are recommended to maintain purity and stability. Always refer to the material safety data sheet (MSDS) for specific handling and storage guidelines.
B2B Procurement Guide
When procuring baicalein, prioritize suppliers with certifications like ISO or GMP to ensure quality. Verify the product's purity through HPLC analysis, aiming for ≥98% purity. Consider bulk purchasing for cost savings, but ensure proper storage facilities are available. Pricing varies based on purity and quantity, typically ranging from $50-$200 per gram. Establish long-term relationships with reputable suppliers to guarantee consistent quality and supply.
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