Azidovaleric Acid

Updated: 2026-09-15

Overview

Azidovaleric Acid, also known as 5-Azidovaleric Acid, is an organic compound containing an azide functional group. It is primarily used in chemical synthesis and pharmaceutical research due to its reactive properties. The compound is a valuable intermediate in the production of more complex molecules, particularly in the field of bioconjugation and click chemistry. Its molecular structure includes a carboxylic acid group and an azide group, making it versatile for various chemical reactions. The compound is typically handled in laboratory settings under controlled conditions to ensure safety.

Physical and Chemical Properties

Azidovaleric Acid is a colorless to pale yellow liquid with a molecular weight of 143.14 g/mol. It is soluble in common organic solvents such as ethanol and acetone, but its solubility in water is limited. The presence of the azide group makes it highly reactive, particularly in click chemistry applications. The compound's reactivity is both an advantage and a safety concern. The azide group can decompose explosively under certain conditions, such as exposure to heat or shock. Therefore, handling requires strict adherence to safety protocols.

Main Applications

Azidovaleric Acid is widely used in organic synthesis as a building block for more complex molecules. Its azide group allows for efficient conjugation with alkyne-containing compounds via click chemistry, a popular method in pharmaceutical and biotechnological research. In the pharmaceutical industry, it serves as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). Additionally, it is used in bioconjugation techniques to label biomolecules for diagnostic and therapeutic purposes.

Safety and Storage

Due to the potential explosiveness of azide compounds, Azidovaleric Acid must be handled with extreme caution. It should be stored in a cool, dry place away from heat sources and open flames. Proper personal protective equipment (PPE), including gloves and goggles, is essential when working with this compound. In case of spillage, avoid creating dust or sparks. Clean up spills immediately using appropriate absorbent materials and dispose of waste in accordance with local regulations. Always consult the material safety data sheet (MSDS) for specific handling instructions.

B2B Procurement Guide

When procuring Azidovaleric Acid, it is crucial to source from reputable suppliers who comply with safety and quality standards. Verify the supplier's certifications and request detailed product specifications, including purity levels and CAS number if available. Consider ordering smaller quantities initially to assess quality and compatibility with your application. Pricing can vary significantly based on quantity and supplier, so obtaining multiple quotes is advisable. Ensure that the supplier provides proper packaging and labeling to meet transportation and storage requirements.