Azelaic Acid[2]
Overview
Azelaic Acid is a naturally occurring saturated dicarboxylic acid found in wheat, rye, and barley. It is also produced industrially by the ozonolysis of oleic acid. The compound is valued for its multifunctional properties, including antibacterial, anti-inflammatory, and keratolytic effects, making it a versatile ingredient in both cosmetic and industrial applications. In the pharmaceutical and cosmetic industries, Azelaic Acid is primarily used for treating skin conditions such as acne and rosacea. Its ability to inhibit bacterial growth and reduce inflammation has made it a popular active ingredient in topical treatments. Industrially, it serves as a precursor for the synthesis of polymers, plasticizers, and lubricants.
Physical and Chemical Properties
Azelaic Acid appears as a white crystalline powder with a molecular weight of 188.22 g/mol. It has a melting point of 106-107°C and a boiling point of 286°C at 100 mmHg. The compound is soluble in hot water, alcohol, and ether but only slightly soluble in cold water. Its density is 1.225 g/cm³, and it exhibits stability under normal storage conditions. Azelaic Acid is known for its mild odor and is non-volatile under ambient conditions. These properties make it suitable for various formulations in cosmetics and industrial applications.
Main Applications
In the cosmetic and pharmaceutical industries, Azelaic Acid is widely used in skincare products for its antibacterial and anti-inflammatory properties. It is effective in treating acne, rosacea, and hyperpigmentation by reducing keratin production and inhibiting the growth of Propionibacterium acnes. Industrially, Azelaic Acid is a key intermediate in the production of polymers, plasticizers, and lubricants. It is also used in the synthesis of adhesives, coatings, and corrosion inhibitors. Its versatility and efficacy make it a valuable component in both personal care and industrial products.
Safety and Storage
Azelaic Acid is generally safe for use in cosmetics and pharmaceuticals but may cause skin and eye irritation upon direct contact. Proper protective equipment, such as gloves and goggles, should be worn when handling the compound. Storage conditions should be cool, dry, and away from direct sunlight and moisture to maintain stability. The compound should be kept in tightly sealed containers to prevent contamination and degradation. Always refer to the material safety data sheet (MSDS) for detailed safety guidelines.
B2B Procurement Guide
When procuring Azelaic Acid, it is essential to verify the supplier's compliance with quality standards such as USP (United States Pharmacopeia) or EP (European Pharmacopoeia). Request a Certificate of Analysis (COA) to confirm purity and quality specifications. Consider factors such as packaging, lead time, and minimum order quantities. Bulk purchases may offer cost advantages, but ensure proper storage facilities are available. Reliable suppliers should provide technical support and documentation to meet regulatory requirements.
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