Overview
AZD4635 is a small-molecule antagonist of the adenosine A2A receptor, developed by AstraZeneca for oncology applications. It targets the immunosuppressive adenosine pathway in the tumor microenvironment, which is exploited by cancers to evade immune detection. By blocking A2A receptors, AZD4635 aims to restore T-cell function and enhance anti-tumor immune responses. This compound is part of a growing class of immunotherapeutic agents designed to overcome resistance to checkpoint inhibitors. Its development reflects the increasing focus on modulating the tumor microenvironment to improve cancer treatment outcomes. AZD4635 is currently in clinical trials, with preliminary data suggesting potential in combination therapies.
Physical and Chemical Properties
AZD4635 has a molecular weight of 431.49 g/mol and a molecular formula of C23H25N7O2. It is typically supplied as a white to off-white powder, soluble in dimethyl sulfoxide (DMSO) and slightly soluble in water. These properties make it suitable for formulation in preclinical and clinical studies. The compound's stability is maintained under recommended storage conditions of -20°C, protected from light and moisture. Its pharmacokinetic profile includes moderate plasma protein binding and a half-life conducive to therapeutic dosing schedules. These characteristics are critical for its intended use in cancer immunotherapy.
Main Applications
AZD4635 is primarily investigated for its role in cancer immunotherapy, particularly in solid tumors such as prostate cancer and non-small cell lung cancer (NSCLC). It is being studied both as a monotherapy and in combination with immune checkpoint inhibitors like PD-1/PD-L1 blockers. Preclinical studies have shown that AZD4635 can reverse adenosine-mediated immunosuppression, leading to enhanced T-cell infiltration and tumor regression. Clinical trials are ongoing to validate these findings in humans, with a focus on safety, efficacy, and optimal dosing regimens. The compound's potential extends to other cancers where adenosine signaling plays a key immunosuppressive role.
Safety and Storage
As an experimental compound, AZD4635 requires careful handling to ensure safety. It should be stored at -20°C in a tightly sealed container, protected from light and moisture to maintain stability. Personal protective equipment (PPE), including gloves and lab coats, is recommended when handling the powder or solutions. Safety data from clinical trials indicate a manageable toxicity profile, with common adverse effects including fatigue and gastrointestinal symptoms. However, long-term safety data are still being collected. Researchers should adhere to institutional biosafety guidelines and dispose of unused material according to local regulations.
B2B Procurement Guide
AZD4635 is available for research purposes through specialized pharmaceutical and chemical suppliers. Buyers should expect to provide documentation of their research intent, as the compound is not yet approved for commercial use. Pricing is typically provided on request and varies based on quantity and purity requirements. Procurement should prioritize suppliers with verified Good Manufacturing Practice (GMP) credentials for clinical-grade material. Lead times can vary due to the compound's experimental status, so advance planning is recommended. Bulk purchases may require additional regulatory approvals, depending on the jurisdiction.
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