Overview
Luteolin-7-O-glucoside, commonly referred to as cynaroside, is a naturally occurring flavonoid glycoside found in various plants such as parsley, celery, and chrysanthemum flowers. It is derived from the aglycone luteolin, bonded to a glucose molecule at the 7-position. This compound is valued for its bioactive properties, including antioxidant and anti-inflammatory effects, making it a sought-after ingredient in pharmaceuticals and nutraceuticals. In traditional medicine, luteolin-7-O-glucoside has been used for its potential health benefits, such as supporting cardiovascular health and reducing oxidative stress. Modern research continues to explore its therapeutic potential, particularly in cancer prevention and neuroprotection. Its stability and solubility profile make it suitable for various formulations in the pharmaceutical and cosmetic industries.
Physical and Chemical Properties
Luteolin-7-O-glucoside is a yellow crystalline powder with a molecular weight of 448.38 g/mol. It is soluble in organic solvents like methanol and ethanol but has limited solubility in water. The compound exhibits a melting point of approximately 250-252°C, indicating its stability under moderate heat conditions. Its chemical structure includes a flavone backbone with a glucose moiety attached, which influences its bioavailability and biological activity. The presence of hydroxyl groups in its structure contributes to its antioxidant properties, enabling it to scavenge free radicals effectively. These properties are critical for its applications in health and wellness products.
Main Applications
Luteolin-7-O-glucoside is widely used in the pharmaceutical industry for its potential therapeutic effects. It is incorporated into formulations aimed at reducing inflammation, combating oxidative stress, and supporting immune function. Research suggests it may also play a role in cancer prevention by inhibiting tumor growth and inducing apoptosis in cancer cells. In the nutraceutical sector, this compound is added to dietary supplements for its antioxidant benefits. It is also a popular ingredient in cosmetic products, where it helps protect the skin from UV-induced damage and premature aging. Its versatility and safety profile make it a valuable component in various B2B applications.
Safety and Storage
Luteolin-7-O-glucoside is generally considered safe for use in pharmaceuticals and cosmetics. However, proper handling is essential to avoid inhalation or skin contact, which may cause irritation. It should be stored in a cool, dry place, protected from light and moisture to maintain its stability and efficacy. For bulk storage, it is recommended to use airtight containers and maintain controlled environmental conditions. Suppliers should provide material safety data sheets (MSDS) to ensure compliance with regulatory standards. Proper storage and handling practices are crucial to preserving the compound's quality and extending its shelf life.
B2B Procurement Guide
When procuring luteolin-7-O-glucoside, it is essential to verify the purity of the compound, typically assessed via HPLC (≥98%). Reputable suppliers should provide certificates of analysis (CoA) and comply with Good Manufacturing Practices (GMP). Batch-to-batch consistency is critical for applications requiring precise dosing, such as pharmaceuticals. Prices vary based on purity, quantity, and supplier reliability. Bulk purchases may offer cost advantages, but buyers should prioritize quality and supplier credibility. Additionally, consider logistical factors such as shipping conditions and lead times to ensure the product arrives in optimal condition. Establishing long-term partnerships with trusted suppliers can enhance supply chain stability.
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