Overview
Aucubin Standard is a certified reference material (CRM) primarily used to standardize analytical methods in pharmaceutical and botanical research. As an iridoid glycoside naturally occurring in Aucuba and Plantago species, it serves as a biomarker for quality assessment of traditional medicines. The standard is produced under strict GMP conditions to ensure batch-to-batch consistency, with typical purity levels exceeding 98% as verified by HPLC-UV/ELSD. In B2B contexts, this standard is essential for laboratories conducting method validation, compound identification, and quantitative analysis. Its role extends to academic research investigating aucubin's pharmacological activities, including hepatoprotective and neuroprotective effects documented in ethnopharmacology studies.
Physical and Chemical Properties
The compound crystallizes as a monoclinic system with characteristic bitter taste and optical rotation [α]D20 = -163° (c=1, water). Its UV spectrum shows maximum absorption at 220nm, useful for HPLC detection. The molecular structure contains a cyclopentanopyran skeleton with β-D-glucose moiety, contributing to its polar nature and water solubility. Thermogravimetric analysis (TGA) indicates decomposition above 180°C without distinct boiling point. The material exhibits stability in acidic conditions (pH 2-6) but undergoes hydrolysis in strong alkaline environments. Fourier-transform infrared spectroscopy (FTIR) reveals key functional groups including hydroxyl (3400 cm−1) and ester carbonyl (1735 cm−1) vibrations.
Main Applications
In pharmaceutical quality control, aucubin standard enables quantification in herbal extracts like Rehmanniae Radix and Eucommiae Cortex per pharmacopeia requirements. It's critical for developing HPLC-UV methods with typical retention times of 8-12 minutes on C18 columns using acetonitrile-water mobile phases. The standard supports research into aucubin's bioactive mechanisms, particularly its inhibition of NF-κB signaling pathway and antioxidant effects. Manufacturers of standardized botanical extracts use it to certify product potency, while contract research organizations (CROs) apply it in bioavailability studies due to its poor intestinal absorption profile.
Safety and Storage
Classified as non-hazardous under GHS criteria, the powder requires standard laboratory precautions including gloves and safety goggles. No special ventilation is needed, but airborne dust should be minimized. Long-term stability is maintained at refrigerated temperatures with desiccants to prevent hydration. For analytical use, working solutions in methanol or water remain stable for 2 weeks when stored at 4°C. Degradation products may form under prolonged light exposure, necessitating amber vials. Disposal should follow institutional protocols for non-toxic organic compounds, though incineration is preferred for large quantities.
B2B Procurement Guide
Reputable suppliers provide detailed certificates of analysis (CoA) listing chromatographic purity, residual solvents, and heavy metal content. Batch-specific HPLC chromatograms with peak purity indices (>990) are essential for method development laboratories. For GMP applications, ensure the supplier offers 21 CFR Part 11-compliant documentation. Bulk purchases (5g+) typically offer 30-50% cost savings but require stability verification. Consider suppliers with ISO 17034 accreditation for reference materials. Lead times vary from 2 weeks for stocked items to 8 weeks for custom purification. Some vendors offer pre-weighed ampoules to minimize handling errors in QC labs.
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