Overview
Arctiin is a lignan glycoside primarily extracted from the seeds of burdock (Arctium lappa), a plant used in traditional Chinese and Japanese medicine. As a bioactive compound, it serves as a precursor to arctigenin, its aglycone form, which exhibits stronger pharmacological effects. Research highlights its role in modulating cellular pathways linked to inflammation and oxidative stress. In industrial contexts, arctiin is standardized for use in dietary supplements and herbal formulations. Its demand has grown due to increasing interest in plant-derived therapeutics, particularly in Asia and Europe, where regulatory frameworks support its use in integrative medicine.
Physical and Chemical Properties
Arctiin crystallizes as a white powder with moderate solubility in polar organic solvents but limited solubility in water. Its stability is influenced by pH and temperature, requiring controlled storage to prevent hydrolysis into arctigenin. The compound's UV absorption peaks at 280 nm, a property utilized for analytical quantification. Thermogravimetric analysis shows decomposition above 200°C, indicating suitability for encapsulation processes in supplement manufacturing. Its glycosidic bond confers relative stability in gastric conditions, enabling targeted release in the intestines for enhanced bioavailability.
Main Applications
Pharmaceutical research focuses on arctiin's potential as an adjuvant in cancer therapy, with studies demonstrating inhibitory effects on tumor angiogenesis. It is also formulated into capsules or tablets for immune support, often combined with other botanicals like astragalus or reishi mushroom. In cosmetics, arctiin appears in anti-aging serums for its antioxidant properties. Industrial-scale extraction typically employs ethanol reflux or supercritical CO2 methods, with yields optimized for cost-effective production in quantities exceeding 100 kg/month.
Safety and Storage
Arctiin is classified as non-hazardous under GHS standards, though prolonged exposure to dust may cause respiratory irritation. Laboratories handling bulk quantities should use NIOSH-approved N95 masks and ensure adequate ventilation. For long-term storage, vacuum-sealed bags with desiccants are recommended to prevent moisture absorption. Stability studies indicate >95% purity retention over 24 months when stored at 4°C in amber glass containers. Transport requires no special permits but should avoid temperature extremes.
B2B Procurement Guide
Bulk buyers should prioritize suppliers offering batch-specific HPLC reports (purity ≥98%) and microbial contamination testing. MOQs typically start at 1 kg for lab-scale purchases, with discounts available for orders exceeding 50 kg. Contract manufacturing organizations (CMOs) in China and Japan dominate production, often providing customized particle size distribution. Key due diligence includes auditing the supplier's pesticide residue controls and cross-checking CAS number authenticity. Payment terms commonly involve 30% upfront for new vendors, with LC payments preferred for international transactions exceeding $10,000.
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