Overview
Ara-G (9-β-D-Arabinofuranosylguanine) is a synthetic nucleoside analog derived from guanine and arabinose. It is primarily used in biomedical research due to its ability to inhibit DNA synthesis, making it a candidate for studying antiviral and anticancer therapies. First synthesized in the late 20th century, Ara-G has been investigated for its potential in treating T-cell malignancies and other proliferative diseases. Its mechanism of action involves incorporation into DNA, leading to chain termination and subsequent cell death in rapidly dividing cells.
Physical and Chemical Properties
Ara-G appears as a white to off-white crystalline powder with a molecular weight of 283.24 g/mol. It is soluble in water and polar organic solvents like DMSO, which facilitates its use in laboratory settings. The compound decomposes at temperatures around 220-225°C, and its stability is best maintained under dry, cool storage conditions (-20°C). Its nucleoside structure is critical for its biological activity, as it mimics natural nucleosides enough to be incorporated into DNA but disrupts further replication.
Main Applications
Ara-G is predominantly used in oncology research, particularly for studying T-cell leukemias and lymphomas. Its ability to selectively target and kill T-cells makes it a valuable tool for understanding these diseases and developing targeted therapies. Beyond oncology, Ara-G has been explored for antiviral applications, especially against DNA viruses. Researchers also use it to study nucleotide metabolism and DNA repair mechanisms in various cell types.
Safety and Storage
As a biologically active compound, Ara-G requires careful handling. It may cause skin or eye irritation, so appropriate personal protective equipment (PPE) such as gloves and goggles should be used. For long-term stability, Ara-G should be stored at -20°C in a tightly sealed container, protected from light and moisture. Solutions should be prepared fresh or stored frozen for short-term use to prevent degradation.
B2B Procurement Guide
When procuring Ara-G for research or industrial use, prioritize suppliers with certifications for analytical standards or pharmaceutical-grade materials. Key specifications include purity (typically ≥98%) and the absence of endotoxins or solvents. Bulk purchases may offer cost advantages, but ensure proper storage facilities are available. Request certificates of analysis (CoA) and material safety data sheets (MSDS) to verify quality and safety compliance.
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