Overview
Apigenin-7 is a bioactive flavonoid and a derivative of apigenin, a naturally occurring compound found in plants like parsley, celery, and chamomile. It is primarily researched for its potential therapeutic effects, including antioxidant and anti-inflammatory properties. Unlike apigenin, its modified structure (7-hydroxy substitution) may influence bioavailability and biological activity. In the B2B sector, apigenin-7 is supplied as a high-purity compound for pharmaceutical formulation, nutraceutical development, and biochemical research. Its demand has grown due to increasing interest in plant-derived therapeutics and evidence of its role in modulating cellular pathways.
Physical and Chemical Properties
Apigenin-7 is characterized by its yellow crystalline form and moderate solubility in organic solvents like DMSO and ethanol. Its melting point ranges between 250–252°C, indicating stability under standard conditions. The compound’s molecular weight (270.24 g/mol) and hydroxyl group at the 7-position contribute to its polarity and interaction with biological targets. Key spectroscopic properties include UV-Vis absorption maxima around 267 nm and 336 nm, useful for analytical identification. Its stability is compromised by prolonged exposure to light or moisture, necessitating airtight, opaque packaging for storage.
Main Applications
In pharmaceuticals, apigenin-7 is investigated for its potential to inhibit cancer cell proliferation and reduce oxidative stress. Preclinical studies suggest benefits in managing neurodegenerative diseases and metabolic disorders. Nutraceutical companies incorporate it into supplements for its purported anti-aging and immune-support effects. The compound also serves as a reference standard in analytical laboratories to quantify apigenin derivatives in plant extracts or formulations. Its use in cosmetics is emerging, leveraging its antioxidant properties to protect skin from environmental damage.
Safety and Storage
While apigenin-7 is generally low in toxicity, handling requires precautions such as gloves and eye protection to prevent irritation. Inhalation of powder should be avoided; work in a fume hood if large quantities are processed. No severe hazards are documented, but material safety data sheets (MSDS) should be reviewed before use. Storage recommendations include keeping the compound in a tightly sealed container at room temperature (15–25°C) with desiccants to prevent moisture absorption. Degradation risks increase if exposed to light, so amber glass containers are preferred.
B2B Procurement Guide
Buyers should prioritize suppliers that provide certificates of analysis (CoA) detailing purity (≥95% by HPLC), residual solvents, and heavy metal content. Batch-to-batch consistency is critical for industrial applications, so request sample testing before bulk orders. Pricing varies significantly based on quantity and purity. For research-grade quantities (1–10 grams), expect $50–$150 per gram, while bulk orders (kilograms) may reduce costs by 20–30%. Consider suppliers compliant with Good Manufacturing Practices (GMP) if the compound is intended for human use.
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