Overview
D-Mannitol is a hexahydric alcohol derived from mannose, commonly found in plants and algae. It is industrially produced by hydrogenation of fructose or extracted from seaweed. As a versatile compound, it is widely utilized in pharmaceuticals, food, and chemical industries due to its unique properties such as low hygroscopicity and osmotic activity. In pharmaceuticals, D-Mannitol serves as an excipient in tablet formulations, providing bulk and improving stability. Its osmotic diuretic properties make it valuable in reducing intracranial and intraocular pressure. In the food industry, it acts as a low-calorie sweetener and texturizing agent, particularly in sugar-free products.
Physical and Chemical Properties
D-Mannitol is a white, odorless crystalline powder with a sweet taste. It has a molecular weight of 182.17 g/mol and a density of 1.52 g/cm³. Its melting point ranges between 166-168°C, and it decomposes at 290-295°C. The compound is freely soluble in water but only slightly soluble in ethanol, making it ideal for aqueous formulations. One of its notable properties is its non-hygroscopic nature, which ensures stability in dry environments. This characteristic is particularly beneficial in pharmaceutical tablet formulations, where moisture sensitivity can compromise product integrity. Additionally, its osmotic activity is leveraged in medical applications to draw fluid out of tissues.
Main Applications
D-Mannitol's primary use is in the pharmaceutical industry, where it functions as an excipient in chewable and orally disintegrating tablets. Its ability to enhance drug dissolution and mask bitter tastes makes it a preferred choice. It is also employed as an osmotic diuretic to treat conditions like cerebral edema and glaucoma. In the food sector, D-Mannitol is used as a sweetener in sugar-free candies, chewing gums, and diabetic-friendly products. Its low glycemic index and minimal caloric content (approximately 1.6 kcal/g) cater to health-conscious consumers. Industrially, it serves as a stabilizer in explosives and a coating agent in plastics and resins.
Safety and Storage
D-Mannitol is generally recognized as safe (GRAS) by regulatory agencies, with low toxicity. However, excessive consumption may lead to gastrointestinal issues such as bloating or diarrhea. In pharmaceutical settings, it is crucial to adhere to recommended dosages to avoid adverse effects. Proper storage involves keeping the compound in a cool, dry place, sealed in moisture-proof containers. Although non-hygroscopic, prolonged exposure to humid conditions can affect its quality. For large-scale procurement, ensure compliance with Good Manufacturing Practices (GMP) and verify supplier certifications to guarantee product purity and safety.
B2B Procurement Guide
When sourcing D-Mannitol for B2B purposes, prioritize suppliers with certifications such as USP, EP, or BP, especially for pharmaceutical applications. Request certificates of analysis (CoA) to confirm purity, which typically ranges from 98% to 101% for pharmaceutical-grade products. Bulk pricing varies based on quantity and purity, with reference prices commonly between $5-$15 per kg. Consider long-term contracts with reliable suppliers to secure stable pricing. For food-grade D-Mannitol, ensure compliance with FDA or EFSA regulations. Always verify logistical capabilities, including storage and transportation conditions, to maintain product integrity during delivery.
Related Manufacturers
- 主营：氧化镁、分析试剂、彩釉调料、甘露醇、甘油缩甲醛、山楂提取物
- 主营：对照品、标准品、当归酸酐、脱水、佛手柑内酯、新当归内酯、补骨脂甲素、补骨脂乙素、羟基芍药苷、阿魏酸松柏酯、水合氧化前胡素、豆甾醇葡萄糖苷
- 主营：莪术二酮、人参皂苷rc、自制对照品、脱水、淫羊藿次苷
- 主营：甘氨酸、溴化物、戊酸鈉、脱水、蒽甲酸、联吡啶、紫苏葶、锂电池、牛磺酸、褪黑素、磷酸铟、新癸酸、赖氨酸、溴化鏻、乙氧基、藏花醛、豆甾醇、羟乙基、维素酶、庚二酸、呋虫胺、丹参素、萘甲醛、槐豆胶、黄柏酮、元明粉
- 主营：小分子现货、科研小分子、单抗、喹啉-21氢、多肽、RAS抑制剂、中间体、医药中间体、实验室用试剂、实验小分子、氯苯甲酸、咪唑乙醇、氧代丙腈、贝达喹啉、贝伐单抗、谷氨酰胺、决明内酯、溴喹唑啉、苯基丙基、乙基己基
- 主营：甘露醇、药用糊精、粘合剂、药用淀粉
- 主营：甘露醇、植提专用酶、防腐剂系列、增稠剂系列
- 主营：甘露醇、食品级添加剂
- 主营：乳酸链球菌素、甜菜碱、富铬酵母、甘露醇、富硒酵母、富锌酵母、肉桂酸钾、茶多酚、植酸钠、富马酸、单宁酸、甘露寡糖、低聚半乳糖、魔芋粉、结冷胶、卡拉胶、海藻酸钠、果胶、黄原胶、酪蛋白酸钠、低聚果糖、低聚木糖、水苏糖、三氯蔗糖、维生素B1、肉桂酸
- 主营：蛋氨酸、阿洛酮糖、赤藓糖醇、l-胱氨酸、l-精氨酸、l-丝氨酸、l-酪氨酸、l-脯氨酸、l-赖氨酸、l-缬氨酸、l-茶氨酸、l-色氨酸、l-亮氨酸、l-谷氨酸、l-苏氨酸、l-苯丙氨酸、l-天冬酰胺、l-异亮氨酸、l-谷氨酰胺、l-天冬氨酸、l-天门冬酰胺、l-羟基脯氨酸、l-天门冬氨酸、大豆低聚糖、甘露寡糖
- 主营：瓜氨酸、甘氨酸、苯丙氨酸、甘露醇、黄原胶、海藻酸钠、羧甲基纤维素钠、氯化胆碱、瓜尔胶、结冷胶、维生素b1、维生素b2、维生素b12、维生素b6、维生素b5、谷氨酰胺、温轮胶、定优胶、丙氨酸、氨基葡萄糖盐酸盐、聚丙烯酸钠、明胶
- 主营：保鲜剂、鲜味剂、营养增补剂、l-苯丙氨酸、l-谷氨酰胺、面包发酵剂、食品添加剂、烘焙调味品、营养强化剂
- 主营：氨基丁酸、甘氨酸、胍基乙酸、L-半胱氨酸盐酸盐、L-谷氨酰胺、L-瓜氨酸、L-精氨酸、L-赖氨酸、L-酪氨酸、L-亮氨酸、L-脯氨酸、L-苏氨酸、L-缬氨酸、D-生物素、支链氨基酸、酪蛋白酸钠、螺旋藻、维生素E、氨糖、一水肌酸、肌醇、菊粉、维生素A、维生素B1、柠檬酸
- 主营：甘露醇、低聚果糖
- 主营：甲酸镍、水苏糖、阻燃剂、甘露醇、柠檬醛、西瓜酮、氢醌酯、卡必醇、消泡剂、磷酸铁、肉桂醇、肉桂醛、碳酸镉、磷酸铝、银墨水、椰油胺、封装胶、化合物、桦木油、稀释剂、羟乙基、乙硫氮、润肤剂、球虫酯、矮壮素、异龙脑
- 主营：甘氨酸、水苏糖、阻燃剂、1680-21-3、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、牛磺酸、褪黑素、磷酸铁、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、磷酸铝、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉、乙氧基