Overview
Granulocyte Colony-Stimulating Factor-Like Protein 2 (G-CSFL2) is a cytokine structurally related to granulocyte colony-stimulating factor (G-CSF). It plays regulatory roles in the immune system and hematopoietic processes, particularly in neutrophil production and differentiation. First identified through genomic studies, G-CSFL2 shares functional similarities with G-CSF but exhibits distinct receptor binding properties. Its discovery has expanded understanding of cytokine networks governing white blood cell development and immune responses.
Physical and Chemical Properties
G-CSFL2 typically exists as a glycosylated protein with molecular weight ranging 20-25 kDa. The protein demonstrates stability in neutral pH buffers but may degrade under extreme pH conditions or prolonged exposure to room temperature. As a cytokine, its biological activity depends on proper three-dimensional folding. The protein contains characteristic four-α-helix bundle structure common to hematopoietic cytokines, with disulfide bonds critical for structural integrity. Analytical methods for verification include SDS-PAGE, Western blot, and bioactivity assays.
Main Applications
In research settings, G-CSFL2 is primarily used to study hematopoietic differentiation pathways and immune cell regulation. It serves as a tool compound for investigating neutrophil development and function in both in vitro and in vivo models. The protein has potential therapeutic applications for conditions involving neutrophil deficiencies. Preclinical studies explore its utility in chemotherapy-induced neutropenia and congenital neutropenia disorders, though clinical applications remain investigational.
Safety and Storage
Proper handling requires biosafety level 1 or 2 precautions depending on concentration. Use gloves and eye protection when handling lyophilized powder or concentrated solutions to prevent accidental exposure. For long-term storage, maintain lyophilized protein at -20°C in desiccated conditions. Reconstituted solutions should be aliquoted to avoid freeze-thaw cycles and stored at 2-8°C for short-term use (typically stable for 1-2 weeks) or at -80°C for extended preservation.
B2B Procurement Guide
When sourcing G-CSFL2 for research purposes, prioritize suppliers providing comprehensive characterization data including bioactivity (typically measured in cell proliferation assays), purity (>95% by SDS-PAGE), and endotoxin levels (<1 EU/μg). Consider application-specific requirements: cell culture-grade material may need lower endotoxin levels than biochemical studies. For therapeutic development, cGMP-grade material with full documentation is essential. Lead times for custom production can range 4-8 weeks depending on specifications.
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