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Aminoindolepropionic Acid

Updated: 2026-07-20

Overview

3-(3-Amino-1H-indol-1-yl)propanoic acid is a specialized organic compound that combines an indole ring with a propanoic acid side chain. It is primarily used in research and pharmaceutical development due to its unique structural features. The compound's amino and carboxylic acid functional groups make it a valuable intermediate in synthetic chemistry. This compound is not commonly found in large-scale industrial applications but is more prevalent in laboratory settings. Its synthesis typically involves multi-step organic reactions, and it is often sourced from specialized chemical suppliers who cater to research institutions and pharmaceutical companies.

Physical and Chemical Properties

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The compound appears as a white to off-white powder under standard conditions. It is soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and methanol but may have limited solubility in water. The presence of both amino and carboxylic acid groups allows it to participate in a variety of chemical reactions, including amide bond formation and esterification. The molecular weight of 204.23 g/mol places it in the category of small organic molecules, which are often used as building blocks for larger, more complex structures. Stability data suggests that it should be stored in a dry environment to prevent degradation, although specific melting and boiling points are not widely documented.

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Main Applications

3-(3-Amino-1H-indol-1-yl)propanoic acid is primarily utilized in pharmaceutical research, where it serves as a precursor or intermediate in the synthesis of more complex molecules. Its indole core is a common motif in many biologically active compounds, including tryptophan derivatives and serotonin analogs. In biochemical studies, this compound may be used to investigate enzyme-substrate interactions or to modify proteins and peptides. Its dual functional groups make it a versatile reagent for conjugation reactions, which are often employed in drug design and development.

Safety and Storage

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As with many research chemicals, proper handling procedures are essential. The compound should be handled in a fume hood to avoid inhalation of dust, and personal protective equipment such as gloves and lab coats should be worn. Although comprehensive toxicity data may be limited, it is prudent to treat it as potentially hazardous. Storage conditions should prioritize stability: a cool, dry environment away from light and moisture is recommended. Sealed containers with desiccants can help prolong shelf life. Disposal should comply with local regulations for organic chemical waste.

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B2B Procurement Guide

For businesses sourcing 3-(3-Amino-1H-indol-1-yl)propanoic acid, selecting a reputable supplier is critical. Key considerations include the supplier's ability to provide certificates of analysis (CoA) that confirm purity and identity through methods like HPLC and NMR spectroscopy. Pricing can vary significantly based on quantity and purity, with research-grade material typically commanding higher prices. Bulk purchases may offer cost savings, but buyers should verify storage stability for long-term use. Lead times may be longer than for common chemicals due to the specialized nature of this compound.

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