Overview
Carbamoylbenzoic acid, also known as benzamide-2-carboxylic acid, is an organic compound primarily used as an intermediate in pharmaceutical synthesis. It is characterized by its white crystalline appearance and moderate solubility in polar solvents. The compound plays a crucial role in the production of various active pharmaceutical ingredients (APIs) and specialized chemicals. Carbamoylbenzoic acid is synthesized through the reaction of benzoic acid derivatives with carbamoylating agents. Its stability and reactivity make it a valuable building block in organic chemistry. Industrial applications often require high-purity grades to ensure consistent performance in downstream processes.
Physical and Chemical Properties
Carbamoylbenzoic acid is a stable compound under normal conditions, with a melting point range of 180-185 °C. It is soluble in water and ethanol, making it suitable for various reaction conditions. The molecular weight is 165.15 g/mol, and its density is approximately 1.3 g/cm³. The compound exhibits moderate reactivity, particularly with strong acids and bases, which can lead to decomposition or unwanted side reactions. Its crystalline structure ensures easy handling and storage, though precautions should be taken to avoid moisture absorption, which can affect its purity and performance in sensitive applications.
Main Applications
Carbamoylbenzoic acid is predominantly used in the pharmaceutical industry as an intermediate for synthesizing active pharmaceutical ingredients (APIs). Its role in organic synthesis extends to the production of specialty chemicals, including dyes and agrochemicals. In pharmaceutical applications, it serves as a precursor for drugs targeting neurological and metabolic disorders. The compound's versatility also makes it useful in academic research, where it is employed in studying reaction mechanisms and developing new synthetic pathways. Its stability and predictable reactivity are key factors in its widespread adoption across industries.
Safety and Storage
Handling carbamoylbenzoic acid requires standard laboratory safety practices, including the use of gloves, goggles, and protective clothing. The compound is not highly toxic but can cause irritation upon contact with skin or eyes. Inhalation of dust should be avoided to prevent respiratory discomfort. Storage conditions should prioritize a cool, dry environment, ideally in airtight containers to minimize exposure to moisture. Prolonged exposure to high temperatures or humidity can degrade the compound, reducing its efficacy in downstream applications. Proper labeling and segregation from incompatible substances, such as strong oxidizers, are essential for maintaining safety and product integrity.
B2B Procurement Guide
When procuring carbamoylbenzoic acid, B2B buyers should prioritize suppliers with verified credentials and a track record of delivering high-purity products. Certificates of analysis (CoA) should be requested to confirm the compound's purity, typically 98% or higher for pharmaceutical applications. Price negotiations should account for bulk purchase discounts, with reference prices ranging from $50 to $100 per kilogram. Buyers should also evaluate logistical considerations, such as shipping conditions and lead times, to ensure a steady supply chain. Establishing long-term contracts with reliable suppliers can mitigate price volatility and ensure consistent quality.
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