Overview
Amentoflavone is a naturally occurring biflavonoid compound derived from plants such as Ginkgo biloba and Selaginella species. It is recognized for its bioactive properties, including antioxidant and anti-inflammatory effects. Historically, it has been used in traditional medicine, and modern research explores its potential in pharmaceuticals and nutraceuticals. Chemically, amentoflavone consists of two flavone units linked together, contributing to its stability and bioactivity. Its unique structure allows it to interact with various biological targets, making it a subject of interest in drug development and health supplement formulations.
Physical and Chemical Properties
Amentoflavone is a yellow crystalline powder with a molecular weight of 538.46 g/mol. It has a melting point above 300°C, indicating high thermal stability. The compound is soluble in organic solvents like DMSO and methanol but only slightly soluble in water, which influences its formulation in products. Its biflavonoid structure grants it strong antioxidant capabilities, enabling it to scavenge free radicals effectively. Additionally, amentoflavone exhibits notable anti-inflammatory activity by inhibiting enzymes like COX-2, which are involved in inflammatory pathways.
Main Applications
Amentoflavone is primarily used in the pharmaceutical and dietary supplement industries. Its antioxidant properties make it valuable in formulations aimed at reducing oxidative stress, a factor in aging and chronic diseases. It is also studied for its potential neuroprotective effects, particularly in conditions like Alzheimer's disease. In traditional medicine, extracts containing amentoflavone are used to support cognitive health and reduce inflammation. Modern applications include its incorporation into capsules, tablets, and liquid supplements, often combined with other bioactive compounds for synergistic effects.
Safety and Storage
Amentoflavone is generally considered safe when used in recommended doses, but excessive intake may cause adverse effects. Proper handling includes wearing protective equipment to avoid inhalation or skin contact, as specified in safety data sheets. Storage should be in a cool, dry environment, protected from light to prevent degradation. The compound is stable under these conditions, but long-term exposure to moisture or high temperatures should be avoided to maintain efficacy.
B2B Procurement Guide
When procuring amentoflavone, prioritize suppliers who provide certificates of analysis (CoA) to verify purity (typically ≥98% by HPLC). Batch-to-batch consistency is critical for research and manufacturing, so request sample testing before large-scale purchases. Pricing varies based on purity and supplier reputation, with reference ranges of $50-$200 per gram. Consider bulk purchasing for cost savings, but ensure the supplier meets Good Manufacturing Practice (GMP) standards to guarantee quality and compliance.
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