Overview
Atrasentan is a selective endothelin A receptor antagonist developed for its potential therapeutic effects in various medical conditions. It is primarily used in research and clinical trials targeting chronic kidney disease and certain cancers, such as prostate cancer. The compound has shown promise in reducing proteinuria and slowing disease progression in preclinical studies. Atrasentan's mechanism of action involves blocking the endothelin-1 pathway, which plays a role in fibrosis and inflammation. As a research chemical, atrasentan is typically handled in laboratory settings by trained professionals. Its development and application are subject to ongoing clinical evaluations, making it a compound of interest in the pharmaceutical and biomedical research sectors.
Physical and Chemical Properties
Atrasentan is a white to off-white powder with a molecular weight of 408.45 g/mol. Its molecular formula is C23H24N2O5, and it has a melting point of approximately 150-152°C. The compound is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in ethanol but practically insoluble in water. This solubility profile is important for its formulation in research and clinical applications. The stability of atrasentan is influenced by storage conditions. It should be kept in a tightly sealed container at -20°C, protected from light and moisture to prevent degradation. These properties are critical for ensuring the compound's efficacy and reliability in experimental and therapeutic contexts.
Main Applications
Atrasentan is primarily utilized in medical research and clinical trials, particularly for conditions like chronic kidney disease (CKD) and prostate cancer. Its ability to selectively inhibit the endothelin A receptor makes it a valuable tool for studying pathways involved in fibrosis, inflammation, and vascular dysfunction. In CKD, atrasentan has been investigated for its potential to reduce proteinuria and slow disease progression. In oncology, atrasentan has been explored for its anti-tumor effects, especially in prostate cancer, where endothelin signaling is implicated in disease advancement. While not yet approved for widespread clinical use, its applications in targeted therapy research highlight its significance in biomedical science.
Safety and Storage
Atrasentan should be handled with care in laboratory or clinical settings. Appropriate personal protective equipment (PPE), including gloves and lab coats, is recommended to avoid skin contact or inhalation. The compound should be stored at -20°C in a tightly sealed container, away from light and moisture, to maintain its stability and prevent degradation. In case of accidental exposure, immediate measures such as rinsing with water or seeking medical attention may be necessary, depending on the route of exposure. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures. Proper storage and handling are essential to ensure both user safety and the integrity of the compound.
B2B Procurement Guide
When procuring atrasentan for B2B purposes, it is essential to verify the supplier's credentials and request a Certificate of Analysis (CoA) to confirm purity and quality. Bulk orders may require special handling and shipping conditions, such as cold chain logistics, to preserve the compound's stability. Pricing can vary significantly, with reference ranges commonly between $500 and $1000 per gram, depending on quantity and supplier. Procurement professionals should also consider regulatory requirements, especially if the compound is intended for clinical trials or export. Establishing a reliable supply chain and ensuring compliance with local and international regulations are critical steps in the procurement process. Long-term storage plans should align with the compound's stability needs.
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