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Ambrettolide

Updated: 2026-07-21

Overview

High-cis Ambrettolide is a premium macrocyclic musk compound derived from hibiscus seed oil or synthesized chemically. As a high-value fragrance ingredient, it is prized for its ability to impart a warm, animalic musk note with exceptional longevity in perfumery. Unlike synthetic nitro musks, it is biodegradable and compliant with IFRA regulations, making it a sustainable choice for modern fragrance formulations. The 'high-cis' designation indicates a purified isomer with superior olfactive properties compared to standard ambrettolide.

Physical and Chemical Properties

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This unsaturated macrocyclic lactone exhibits remarkable stability against oxidation and hydrolysis, even in alkaline formulations like soaps. Its low vapor pressure ensures slow release of the musk scent, providing base-note functionality in perfumes. The compound's lipophilic nature allows excellent substantivity on skin and fabric. Technical specifications typically require ≥90% cis-isomer content (determined by GC-MS) as the trans-isomer exhibits weaker olfactory characteristics. Impurities like fatty acids are minimized through molecular distillation during production.

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Main Applications

In fine fragrances, high-cis ambrettolide serves as a musky fixative that blends well with woody, amber, and floral accords. It is particularly valued in oriental and chypre compositions for adding sensual depth. The personal care industry incorporates it into premium shampoos, lotions, and deodorants at 0.1-1% concentrations. Its stability in detergents makes it suitable for luxury laundry products. Some niche applications include scented candles and home fragrance diffusers where long-lasting musk notes are desired.

Safety and Storage

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Classified as non-hazardous under GHS, ambrettolide requires standard chemical handling precautions. Use nitrile gloves when handling concentrated material, as prolonged skin contact may cause mild irritation. For optimal shelf life (typically 2 years), store in amber glass or HDPE containers under nitrogen atmosphere at 15-25°C. Bulk storage tanks should use stainless steel with inert gas blanketing to prevent oxidation. Compatibility testing is recommended when blending with reactive fragrance ingredients.

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B2B Procurement Guide

Reputable suppliers provide certificates of analysis including GC purity, cis/trans ratio, acid value, and residual solvent testing. For fragrance applications, request olfactory evaluation reports from the manufacturer's perfumers. Consider ordering small test quantities (100g-1kg) to evaluate compatibility with your formulations before bulk purchases. Sea freight requires proper IMO classification (usually not regulated as dangerous goods). For air shipments, verify IATA regulations as some carriers restrict liquid fragrance compounds.

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