Overview
Alpha-Tocopherolquinone (α-TQ) is a quinone derivative of alpha-tocopherol, the most biologically active form of vitamin E. It is formed during the antioxidant activity of vitamin E and participates in redox cycling within cells. α-TQ is studied for its potential roles in cellular signaling and protection against oxidative stress. In industrial and research contexts, α-TQ is synthesized for use in pharmaceuticals and nutraceuticals. Its stability and redox properties make it valuable for studying oxidative mechanisms and developing therapeutic agents.
Physical and Chemical Properties
α-Tocopherolquinone is a yellow to brown crystalline powder with limited solubility in water but high solubility in organic solvents like ethanol and dimethyl sulfoxide (DMSO). Its molecular structure includes a quinone moiety, which is critical for its electron-accepting capabilities. The compound has a melting point around 90-95°C and is sensitive to light and oxygen, requiring careful storage. Its lipophilic nature allows it to integrate into cell membranes, where it modulates oxidative reactions.
Main Applications
α-TQ is primarily used in pharmaceutical research to investigate oxidative stress and mitochondrial function. It serves as a reference standard in assays measuring vitamin E metabolism and redox balance. In nutraceuticals, α-TQ is explored for its potential health benefits, including neuroprotection and anti-aging effects. Industrial applications include its use as an intermediate in synthesizing vitamin E analogs and other bioactive compounds.
Safety and Storage
Alpha-Tocopherolquinone should be handled in a fume hood with appropriate personal protective equipment (PPE) to avoid skin contact or inhalation. It is stable under inert gas but degrades upon prolonged exposure to air or light. Storage recommendations include sealing the compound in amber glass vials under nitrogen or argon and maintaining temperatures below 4°C for long-term preservation. Material Safety Data Sheets (MSDS) should be consulted for hazard-specific guidelines.
B2B Procurement Guide
When procuring α-TQ, prioritize suppliers with certifications (e.g., ISO, GMP) and batch-specific Certificates of Analysis (CoA). Key specifications to verify include purity (≥95% by HPLC), residual solvents, and heavy metal content. Bulk purchases may offer cost advantages, but ensure proper storage facilities are available. For research-grade quantities, opt for suppliers specializing in fine chemicals with traceable synthesis methods.
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