Overview
Alkyl-PEG-C is a versatile polyethylene glycol (PEG) derivative functionalized with an alkyl chain and a carboxyl group. It bridges hydrophobic (alkyl) and hydrophilic (PEG) properties, enabling applications in drug delivery, bioconjugation, and nanotechnology. Its customizable structure allows precise tuning for specific industrial or biomedical uses. PEG derivatives like Alkyl-PEG-C are prized for their biocompatibility and non-immunogenicity, making them ideal for pharmaceutical formulations. The carboxyl group provides a reactive site for further chemical modifications, enhancing its utility in targeted therapies and biomaterial coatings.
Physical and Chemical Properties
Alkyl-PEG-C typically appears as a white powder or viscous liquid, depending on molecular weight. Its solubility in water and organic solvents like ethanol or DMF facilitates easy integration into diverse formulations. The compound’s density (~1.1-1.2 g/cm³) and melting point (40-60°C) vary with PEG chain length and alkyl group size. Key chemical properties include its hydrophilic PEG backbone and the reactive carboxyl terminus, which can form esters or amides. The alkyl chain introduces hydrophobic interactions, useful for micelle formation or lipid bilayer integration. Stability is high under neutral pH but may degrade under strong acids/bases.
Main Applications
In pharmaceuticals, Alkyl-PEG-C is used to modify drug molecules, improving solubility and prolonging circulation time. Its carboxyl group enables covalent attachment to proteins, antibodies, or nanoparticles for targeted delivery systems. Beyond therapeutics, it serves as a surface modifier for medical devices and diagnostic tools, reducing fouling and enhancing biocompatibility. In nanotechnology, it stabilizes liposomes and quantum dots. Industrial applications include lubricant additives and specialty coatings requiring hydrophilic-hydrophobic balance.
Safety and Storage
Alkyl-PEG-C is generally low-toxicity but requires standard lab handling (gloves, goggles). Avoid inhalation of powders and direct skin contact. Storage at 2-8°C in airtight containers prevents moisture absorption and degradation. Disposal should follow local regulations for organic compounds. For large-scale use, conduct compatibility tests with other formulation components to avoid unintended reactions. Stability data sheets from suppliers provide batch-specific guidelines.
B2B Procurement Guide
When sourcing Alkyl-PEG-C, specify PEG molecular weight (e.g., PEG-1000, PEG-2000) and alkyl chain length (C4, C12, etc.). Purity (≥95% or higher) and functional group integrity (confirmed via NMR or HPLC) are critical for sensitive applications. Suppliers often offer custom synthesis; request COA (Certificate of Analysis) and MSDS. Bulk pricing tiers apply; negotiate based on volume. Lead times vary for tailored derivatives. Preferred vendors include specialty chemical manufacturers with GMP capabilities for biomedical use.